WormBase Tree Display for Variation: WBVar00093946

WBVar00093946 Evidence: Paper_evidence: WBPaper00040713
  Name: Public_name: ok2851
    HGVSg: CHROMOSOME_III:g.4167295_4168871delinsTCTCGATTCTATGGACTAAAATTAAACAGA
  Sequence_details: SMap: S_parent: Sequence: C16C10
    Flanking_sequences: ctccctgattctctcgattctatggacttc aagaataaataaagtcgtaatttttttttc
    Mapping_target: C16C10
    Type_of_mutation: Insertion: TCTCGATTCTATGGACTAAAATTAAACAGA
      Deletion
    PCR_product: OK2851_external
      OK2851_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00037361
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00007627
      WBGene00007626
    Transcript: C16C10.6.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        cDNA_position: ?-935
        CDS_position: ?-935
        Protein_position: ?-312
        Intron_number: 1-2/3
        Exon_number: 1-3/4
      C16C10.5.1 VEP_consequence: 3_prime_UTR_variant
        VEP_impact: MODIFIER
        cDNA_position: 1240-?
        Exon_number: 10/10
  Isolation: Mutagen: EMS
  Description: Phenotype: WBPhenotype:0000055 Paper_evidence: WBPaper00040713
        Curator_confirmed: WBPerson712
        Remark: Balanced heterozygous hermaphrodites produce wildtype and arrested progeny. | Arrested larvae are the size of wild-type mid-L2 larvae. | ccdc-55(ok2851) homozygous animals remain arrested until they die at approximately 2 weeks of age. Paper_evidence: WBPaper00040713
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00040713
          Curator_confirmed: WBPerson712
      WBPhenotype:0000644 Paper_evidence: WBPaper00040713
        Curator_confirmed: WBPerson712
        Remark: Animals exhibit late larval-onset paralysis. Paper_evidence: WBPaper00040713
            Curator_confirmed: WBPerson712
      WBPhenotype:0001355 Paper_evidence: WBPaper00040713
        Curator_confirmed: WBPerson712
        Remark: The gonad in the arrested ccdc-55(ok2851) larvae at 54 h is significantly longer than in the size-matched wildtype animals. Paper_evidence: WBPaper00040713
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00040713
          Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000072 Paper_evidence: WBPaper00040713
        Curator_confirmed: WBPerson712
        Remark: No overt defects are apparent in overall body morphology. Paper_evidence: WBPaper00040713
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00040713
          Curator_confirmed: WBPerson712
      WBPhenotype:0000196 Paper_evidence: WBPaper00040713
        Curator_confirmed: WBPerson712
        Remark: ccdc-55(ok2851) DTCs are normal in general morphology. Paper_evidence: WBPaper00040713
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00040713
          Curator_confirmed: WBPerson712
      WBPhenotype:0000709 Paper_evidence: WBPaper00040713
        Curator_confirmed: WBPerson712
        Remark: No overt defects are apparent in pharyngeal morphology. Paper_evidence: WBPaper00040713
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00040713
          Curator_confirmed: WBPerson712
      WBPhenotype:0000710 Paper_evidence: WBPaper00040713
        Curator_confirmed: WBPerson712
        Remark: No overt defects are apparent in intestinal morphology. Paper_evidence: WBPaper00040713
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00040713
          Curator_confirmed: WBPerson712
      WBPhenotype:0000778 Paper_evidence: WBPaper00040713
        Curator_confirmed: WBPerson712
        Remark: No overt defects are apparent in ingestion of mCherry-labeled bacteria. Paper_evidence: WBPaper00040713
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00040713
          Curator_confirmed: WBPerson712
      WBPhenotype:0001006 Paper_evidence: WBPaper00040713
        Curator_confirmed: WBPerson712
        Remark: No overt defects are apparent in rate of pharyngeal pumping. Paper_evidence: WBPaper00040713
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00040713
          Curator_confirmed: WBPerson712
  Reference: WBPaper00040713
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele