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WormBase Tree Display for Variation: WBVar00094041

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Name Class

WBVar00094041NamePublic_nameok2954
Other_nameCE36100:p.Ala196GlufsTer19
C12C8.2a.1:c.587_833del
HGVSgCHROMOSOME_I:g.9329188_9329881del
Sequence_detailsSMapS_parentSequenceC12C8
Flanking_sequencesctgttgacgttgaaaaagaaaaggattttgagttgttacagtatcatcttatgataattg
Mapping_targetC12C8
Type_of_mutationDeletion
PCR_productOK2954_external
OK2954_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00037169
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00007533
TranscriptC12C8.2a.1 (11)
C12C8.2b.1VEP_consequencesplice_acceptor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
Intron_number3/3
Exon_number4/4
IsolationMutagenEMS
DescriptionPhenotypeWBPhenotype:0001236Paper_evidenceWBPaper00042204
Curator_confirmedWBPerson2987
Remark"We obtained deletion mutants for two genes involved in BCAA breakdown (mce-1 and pcca-1) and one from the methionine metabolism pathway (cbl-1) (Figure 3). These deletions were introduced into the Pacdh-1::GFP dietary sensor strain. Deletions in mce-1 and pcca-1 both caused increased GFP expression on all three diets, and a deletion in cbl-1 caused increased GFP on Comamonas DA1877, but not on E_coli OP50 (Figure S5)."Paper_evidenceWBPaper00042204
Curator_confirmedWBPerson2987
Phenotype_assayGenotypePacdh-1::GFPPaper_evidenceWBPaper00042204
Curator_confirmedWBPerson2987
ReferenceWBPaper00042204
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele