WormBase Tree Display for Variation: WBVar00094698

WBVar00094698 Evidence: Paper_evidence: WBPaper00005108
  Name: Public_name: or198
    Other_name: or198ts
      F11H8.1.1:c.785C>T
      F11H8.1.2:c.785C>T
      CE34538:p.Ala262Val
    HGVSg: CHROMOSOME_III:g.7022972C>T
  Sequence_details: SMap: S_parent: Sequence: F11H8
    Flanking_sequences: aatgggttctcgaaagagcaagtcttcgtg agaaaaatacaatattcgaggtgtggatcg
    Mapping_target: F11H8
    Type_of_mutation: Substitution: c t
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00007295
    Laboratory: EU
    Status: Live
  Affects: Gene: WBGene00004341
    Transcript: F11H8.1.1 (12)
      F11H8.1.2 (12)
    Interactor: WBInteraction000501446
      WBInteraction000502221
      WBInteraction000503984
      WBInteraction000542282
      WBInteraction000542283
      WBInteraction000557509
  Genetics: Interpolated_map_position: III -0.843768
  Description: Phenotype: WBPhenotype:0000050 Paper_evidence: WBPaper00033469
        Curator_confirmed: WBPerson712
        Remark: Embryonic viability drops significantly for the progeny of animals raised at temperature above 20 deg C. Paper_evidence: WBPaper00033469
            Curator_confirmed: WBPerson712
        Penetrance: Complete: Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
      WBPhenotype:0000119 Paper_evidence: WBPaper00033119
        Curator_confirmed: WBPerson2021
        Remark: rfl-1 mutants had increased accumulation of MEL-26 during meiosis Paper_evidence: WBPaper00033119
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00033119
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: MEL-26 antibody staining Paper_evidence: WBPaper00033119
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000154 Paper_evidence: WBPaper00033469
        Curator_confirmed: WBPerson712
        Remark: Most larva grown at the non-permissive temperature mature into sterile adults or fertile pVul adults or adults with reduced fertility. Paper_evidence: WBPaper00033469
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: greater than 24 deg C Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
      WBPhenotype:0000688 Paper_evidence: WBPaper00033469
        Curator_confirmed: WBPerson712
        Remark: Most larva grown at the non-permissive temperature mature into sterile adults or fertile pVul adults or adults with reduced fertility. Paper_evidence: WBPaper00033469
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: greater than 24 deg C Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
      WBPhenotype:0000697 Paper_evidence: WBPaper00033469
        Curator_confirmed: WBPerson712
        Remark: Most larva grown at the non-permissive temperature mature into sterile adults or fertile pVul adults or adults with reduced fertility. Paper_evidence: WBPaper00033469
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: greater than 24 deg C Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
      WBPhenotype:0000760 Paper_evidence: WBPaper00033469
        Curator_confirmed: WBPerson712
        Remark: The first mitotic spindle was mis-oriented in embryos from RNAi vector-fed animals that had undergone cytokinesis. Paper_evidence: WBPaper00033469
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
      WBPhenotype:0000779 Paper_evidence: WBPaper00033469
        Curator_confirmed: WBPerson712
        Remark: Embryos upshifted to 26 deg C at the 16-50 cell stage arrested after elongation or beyond the three-fold stage. Paper_evidence: WBPaper00033469
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 26 deg C Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
      WBPhenotype:0001130 Paper_evidence: WBPaper00033469
        Curator_confirmed: WBPerson712
        Remark: 54% of embryos from RNAi vector-fed animals fail to complete cytokinesis. Paper_evidence: WBPaper00033469
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
      WBPhenotype:0002501 Paper_evidence: WBPaper00033469
        Curator_confirmed: WBPerson712
        Remark: 77% of embryos from RNAi vector-fed animals that had undergone cytokinesis had ectopic cleavage furrow(s). Paper_evidence: WBPaper00033469
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00033469
              Curator_confirmed: WBPerson712
  Reference: WBPaper00033119
    WBPaper00033469
    WBPaper00016952
    WBPaper00026118
  Method: Substitution_allele