WormBase Tree Display for Variation: WBVar00095062

WBVar00095062 Evidence: Paper_evidence: WBPaper00034719
  Name: Public_name: oz36
    Other_name: CE31860:p.Gln276Ter
      ZK1128.2a.1:c.826C>T
      CE31861:p.Gln261Ter
      ZK1128.2b.1:c.781C>T
    HGVSg: CHROMOSOME_III:g.10116042C>T
  Sequence_details: SMap: S_parent: Sequence: ZK1128
    Flanking_sequences: gtctagtctgaagcccctgcaaaatcgtctg aacgcttcggagatgacgttaaaattatgat
    Mapping_target: ZK1128
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00034719
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: BS
    Status: Live
  Affects: Gene: WBGene00014228
    Transcript: ZK1128.2b.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: ZK1128.2b.1:c.781C>T
        HGVSp: CE31861:p.Gln261Ter
        cDNA_position: 781
        CDS_position: 781
        Protein_position: 261
        Exon_number: 5/6
        Codon_change: Caa/Taa
        Amino_acid_change: Q/*
      ZK1128.2a.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: ZK1128.2a.1:c.826C>T
        HGVSp: CE31860:p.Gln276Ter
        cDNA_position: 833
        CDS_position: 826
        Protein_position: 276
        Exon_number: 5/7
        Codon_change: Caa/Taa
        Amino_acid_change: Q/*
    Interactor: WBInteraction000051748
  Genetics: Interpolated_map_position: III 1.836
    Mapping_data: In_multi_point: 3173
        3175
        3176
        3177
        3178
  Description: Phenotype: WBPhenotype:0000031 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: At 25C, mett-10(oz36) animals are Gro Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000052 Paper_evidence: WBPaper00034719
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: At 25C, mett-10(oz36) animals are Mel Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
          similar phenotype to g38 at 25C Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
            25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Maternal
      WBPhenotype:0000085 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: At 25C, mett-10(oz36) animals exhibit distension of the intestinal lumen Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000688 Paper_evidence: WBPaper00034719
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: At 25C, mett-10(oz36) animals are sterile (Ste) Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
          similar phenotype to g38 at 25C- escapers that develop to adulthood are sterile; some oogenesis and yolk synthesis. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
            25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000697 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: At 25C, mett-10(oz36) animals are Pvl Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001033 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: Ectopic proliferation near the "loop" region of the germ line normally occupied by cells in meiotic pachytene Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001038 Paper_evidence: WBPaper00034719
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: "Late-onset tumorous" phenotype: the distal proliferative zone progressively increases in length as the animals age. Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
          impenetrant late-onset tumorous germline phenotype, strongest at 15C. oz36 males exhibit some tumorous germ lines. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 15 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0001215 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: Ectopic phospho-histone-3 (pH3, metaphase marker) nuclei were seen in mett-10(oz36) mutants, indicative of ectopic mitosis Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
  Reference: WBPaper00012645
    WBPaper00034719
    WBPaper00022126
  Method: Substitution_allele