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WormBase Tree Display for Variation: WBVar00145483

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Name Class

WBVar00145483NamePublic_namegk28
HGVSgCHROMOSOME_I:g.9793653_9795633del
Sequence_detailsSMapS_parentSequenceCHROMOSOME_I
Flanking_sequencesattgcgatatacataatttcaaaaaaaaaaatcgggatccgctcagtctacaatcgaaaa
Mapping_targetCHROMOSOME_I
Type_of_mutationDeletion
PCR_productGK28_external
GK28_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00035494
LaboratoryVC
PersonWBPerson427
WBPerson2838
KO_consortium_allele
StatusLive
AffectsGeneWBGene00009164
TranscriptF26E4.11.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
VEP_impactHIGH
cDNA_position?-1418
CDS_position?-1418
Protein_position?-473
Intron_number1-4/6
Exon_number1-5/7
InteractorWBInteraction000520511
DescriptionPhenotype_not_observedWBPhenotype:0000523Paper_evidenceWBPaper00030999
Curator_confirmedWBPerson2987
Remarkhrd-1(gk28) animals exhibited a wild type growth rate in the presence of 5 mM DTTPaper_evidenceWBPaper00030999
Curator_confirmedWBPerson2987
hrd-1(gk28) animals exhibited a wild type growth rate in the presence of 5 μM thapsigarginPaper_evidenceWBPaper00030999
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00004908Paper_evidenceWBPaper00030999
Curator_confirmedWBPerson2987
WBMol:00002963Paper_evidenceWBPaper00030999
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentEggs were laid on plates containing 5 millimolar DTT for 2 hours and analyzed after 72 hoursPaper_evidenceWBPaper00030999
Curator_confirmedWBPerson2987
Eggs were laid on plates containing 5 micromolar thapsigargin for 2 hours and analyzed after 72 hoursPaper_evidenceWBPaper00030999
Curator_confirmedWBPerson2987
WBPhenotype:0000676Paper_evidenceWBPaper00030999
Curator_confirmedWBPerson2987
Remarkhrdl-1(gk28) deletion did not affect the growth rate (Fig. 3A).Paper_evidenceWBPaper00030999
Curator_confirmedWBPerson2987
WBPhenotype:0001236Paper_evidenceWBPaper00030999
Curator_confirmedWBPerson2987
Remark"Interestingly, hrd-1 RNAi treatment induced the hsp-4::gfp expression in an ire-1-dependent manner, while hrdl-1(gk28) and marc-6(RNAi) did not induce it (Fig. 4A)."Paper_evidenceWBPaper00030999
Curator_confirmedWBPerson2987
WBPhenotype:0001506Paper_evidenceWBPaper00060631
Curator_confirmedWBPerson712
RemarkAnimals lacking full-length hrdl-1 reversed less than wild-type animals, but this was not statistically significant (Figure 1A).Paper_evidenceWBPaper00060631
Curator_confirmedWBPerson712
ReferenceWBPaper00030999
WBPaper00060631
RemarkLast updated on 29 Nov 2002
Generated by the C. elegans Gene Knockout Consortium
Allele sequenced by Yohei SasagawaCurator_confirmedWBPerson2970
Sequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele