WormBase Tree Display for Variation: WBVar00145619

WBVar00145619 Name: Public_name: gk212
    Other_name: Y60A3A.12.1:c.136_694-88del
    HGVSg: CHROMOSOME_V:g.19914410_19915785del
  Sequence_details: SMap: S_parent: Sequence: Y60A3A
    Flanking_sequences: aaatcactttttatcgataattttagtgaa gggttttgaagcagcacactgtgattctcc
    Mapping_target: Y60A3A
    Type_of_mutation: Deletion
    PCR_product: gk212_external
      gk212_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00040537
    Laboratory: VC
    Person: WBPerson427
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00000499
    Transcript: Y60A3A.12.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: Y60A3A.12.1:c.136_694-88del
        cDNA_position: 186-?
        CDS_position: 136-?
        Protein_position: 46-?
        Intron_number: 3-7/15
        Exon_number: 3-7/16
  Isolation: Mutagen: TMP/UV
  Description: Phenotype: WBPhenotype:0001755 Paper_evidence: WBPaper00029176
        Curator_confirmed: WBPerson557
        Remark: UV-C induced mitotic germ cell arrest was reduced in these mutants. Paper_evidence: WBPaper00029176
            Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Germ cell apoptosis was measured following exposure to 100 joules per square meter UV-C. Paper_evidence: WBPaper00029176
              Curator_confirmed: WBPerson557
      WBPhenotype:0001756 Paper_evidence: WBPaper00029176
        Curator_confirmed: WBPerson557
        Remark: chk-2(gk212) mutants failed to exhibit increased germ cell cell death upon UV-C treatment. Paper_evidence: WBPaper00029176
            Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Germ cell apoptosis was measured following exposure to 100 joules per square meter UV-C. Paper_evidence: WBPaper00029176
              Curator_confirmed: WBPerson557
  Reference: WBPaper00029176
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele