WormBase Tree Display for Variation: WBVar00145737

WBVar00145737 Name: Public_name: gk330
    Other_name: D2021.2a.1:c.724+5_1101-15del
    HGVSg: CHROMOSOME_X:g.8553778_8554569del
  Sequence_details: SMap: S_parent: Sequence: D2021
    Flanking_sequences: gacgatcaaaagtccacaaatcctaggtaa gtgaataattttagaatagggacactggat
    Mapping_target: D2021
    Type_of_mutation: Deletion
    PCR_product: gk330_external
      gk330_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00036054
    Laboratory: VC
    Person: WBPerson427
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00044071
    Transcript: D2021.2b.1 VEP_consequence: splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        Intron_number: 1/4
        Exon_number: 1/5
      D2021.2a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: D2021.2a.1:c.724+5_1101-15del
        Intron_number: 6-8/12
        Exon_number: 7-8/13
  Isolation: Mutagen: TMP/UV
  Genetics: Mapping_data: In_multi_point: 5569
  Description: Phenotype: WBPhenotype:0000039 Paper_evidence: WBPaper00045834
        Curator_confirmed: WBPerson2987
        Remark: dhhc-14(gk330) mutants showed a decrease in mean and median lifespan and a reduced time to 90% mortality. (Table 2, Figure 4A) Paper_evidence: WBPaper00045834
            Curator_confirmed: WBPerson2987
    Phenotype_not_observed: WBPhenotype:0000315 Paper_evidence: WBPaper00045834
        Curator_confirmed: WBPerson2987
        Remark: Additional file 12 Paper_evidence: WBPaper00045834
            Curator_confirmed: WBPerson2987
      WBPhenotype:0000643 Paper_evidence: WBPaper00045834
        Curator_confirmed: WBPerson2987
        Remark: Animals did not show a significant difference in age-related decline of thrashing rate, compared to wild type (N2) controls (Additional file 9) Paper_evidence: WBPaper00045834
            Curator_confirmed: WBPerson2987
      WBPhenotype:0001700 Paper_evidence: WBPaper00045834
        Curator_confirmed: WBPerson2987
        Remark: Figure 3 A-B Paper_evidence: WBPaper00045834
            Curator_confirmed: WBPerson2987
      WBPhenotype:0001726 Paper_evidence: WBPaper00045834
        Curator_confirmed: WBPerson2987
        Remark: Wild-type N2 animals had an average length of 1222 μm and width of 78 μm (Additional file 6). Mutants for dhhc-14(gk330) showed no significant changes in body length or width. Paper_evidence: WBPaper00045834
            Curator_confirmed: WBPerson2987
      WBPhenotype:0001727 Paper_evidence: WBPaper00045834
        Curator_confirmed: WBPerson2987
        Remark: Wild-type N2 animals had an average length of 1222 μm and width of 78 μm (Additional file 6). Mutants for dhhc-14(gk330) showed no significant changes in body length or width. Paper_evidence: WBPaper00045834
            Curator_confirmed: WBPerson2987
      WBPhenotype:0004023 Paper_evidence: WBPaper00045834
        Curator_confirmed: WBPerson2987
        Remark: Additional file 8 Paper_evidence: WBPaper00045834
            Curator_confirmed: WBPerson2987
  Reference: WBPaper00045834
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele