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WormBase Tree Display for Variation: WBVar00240997

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Name Class

WBVar00240997NamePublic_nameq75
Other_nameH20J04.8.1:c.228_230+2del
HGVSgCHROMOSOME_II:g.4324594_4324598del
Sequence_detailsSMapS_parentSequenceH20J04
Flanking_sequencesgaatacgctgtatcttcataataatcgaatgcgtagttttccgaaaaacgagcgaaaagt
Mapping_targetH20J04
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00022554
LaboratoryJK
StatusLive
AffectsGeneWBGene00003390
TranscriptH20J04.8.1VEP_consequencesplice_donor_variant,coding_sequence_variant
VEP_impactHIGH
HGVScH20J04.8.1:c.228_230+2del
cDNA_position234-?
CDS_position228-?
Protein_position76-?
Intron_number2/3
Exon_number2/4
InteractorWBInteraction000501294
WBInteraction000501295
WBInteraction000501296
WBInteraction000501297
WBInteraction000555214
GeneticsInterpolated_map_positionII-4.88183
Mapping_dataIn_multi_point2790
In_pos_neg_data7380
DescriptionPhenotypeWBPhenotype:0000031Paper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
RemarkMog-2 alleles grew significantly slower than wild type siblings at 15 deg C and 20 deg C. Furthermore, mog-2(q75) larvae required more time to develop into adults than mog-2(ok1221).Paper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive20, 25Paper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
WBPhenotype:0000052 (11)
WBPhenotype:0000385Paper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
RemarkXX mog mutant adults produce two to five times the normal number of spermPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Phenotype_assayTemperature25CPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
WBPhenotype:0000683Paper_evidenceWBPaper00001883
WBPaper00038354
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
RemarkGerm cells that would normally become oocytes have been transformed into sperm insteadPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
While mostly fertile at 15 deg C, more than 20% of mog-2 hermaphrodites developed as somatic females that made excess of sperm and no oocytes at 20 deg C. At 25 deg C, most germ lines are fully masculinized with only 1% of fertile progeny producing sperm and oocytes.Paper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
ts Mog, at 25C hermaphrodite germline makes mostly sperm, rare abnormal oocytes.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
PenetranceHigh81 percentPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
20, 25Paper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_assayTemperature25CPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
WBPhenotype:0000688Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkMostly fertile at 15 degrees.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001360Paper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
WBPhenotype:0001369Paper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
RemarkU2 snRNA was not coimmunoprecipitated in the absence of MOG-2 in a mog-2(ok1221) null mutant.Paper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
WBPhenotype:0001694Paper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
RemarkIn most mog-2-mog-6 homozygotes grown at 25C, spermatogenesis begins at the normal time and continues without switching to oogenesisPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Phenotype_assayTemperature25CPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0000416Paper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
RemarkAnimals produce refractile yolk dropletsPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Phenotype_assayTemperature25CPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
WBPhenotype:0000508Paper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
RemarkWhile an alternatively spliced variant of the rpl-7A was detected in smg-1 and smg-1; mog-2 mutants, it was observed neither in wild type, nor in mog-2 animals.Paper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00038354
Curator_confirmedWBPerson712
WBPhenotype:0000695Paper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
RemarkAnimals grown at 25C have a normal vulvaPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
Phenotype_assayTemperature25CPaper_evidenceWBPaper00001883
Curator_confirmedWBPerson2021
ReferenceWBPaper00038354
WBPaper00001883
WBPaper00012610
MethodDeletion_allele