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WormBase Tree Display for Variation: WBVar00241155

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Name Class

WBVar00241155NamePublic_nameq544
Other_nameT23D8.9c.1:c.558G>A
T23D8.9b.1:c.*248G>A
CE18959:p.Val319=
T23D8.9a.1:c.957G>A
CE50477:p.Val186=
HGVSgCHROMOSOME_I:g.9982363C>T
Sequence_detailsSMapS_parentSequenceT23D8
Flanking_sequencestcctcacatgaaacactgcgcaaatcaggttttcaaattttcaactgtatcataatggga
Mapping_targetT23D8
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00025233
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00022575
WBStrain00022587
WBStrain00022589
WBStrain00022636
LaboratoryJK
StatusLive
AffectsGeneWBGene00006379
TranscriptT23D8.9b.1VEP_consequence3_prime_UTR_variant
VEP_impactMODIFIER
HGVScT23D8.9b.1:c.*248G>A
cDNA_position968
Exon_number7/11
T23D8.9c.1VEP_consequencesynonymous_variant
VEP_impactLOW
HGVScT23D8.9c.1:c.558G>A
HGVSpCE50477:p.Val186=
cDNA_position558
CDS_position558
Protein_position186
Exon_number4/8
Codon_changegtG/gtA
Amino_acid_changeV
T23D8.9a.1VEP_consequencesynonymous_variant
VEP_impactLOW
HGVScT23D8.9a.1:c.957G>A
HGVSpCE18959:p.Val319=
cDNA_position965
CDS_position957
Protein_position319
Exon_number7/12
Codon_changegtG/gtA
Amino_acid_changeV
Interactor (18)
GeneticsInterpolated_map_positionI4.13429
Mapping_dataIn_multi_point5650
DescriptionPhenotypeWBPhenotype:0000095Paper_evidenceWBPaper00033137
Curator_confirmedWBPerson557
RemarkThere is an increase in the number of dorsal non-muscle coelomocytes (CCs) and ventral sex myoblasts derived from the M lineage in these animals.Paper_evidenceWBPaper00033137
Curator_confirmedWBPerson557
Phenotype_assayGenotypeintrinsic CC::gfp; hlh-8::gfpPaper_evidenceWBPaper00033137
Curator_confirmedWBPerson557
WBPhenotype:0000318Paper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
RemarkVas deferens precursor cells undergo divisions with a lengthened cell cycle.Paper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
WBPhenotype:0000822Paper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
RemarkMale gonads expressed multiple hermaphrodite-specific gonadal markers, in addition, some males contained gonadal cells that were characteristic in morphology of hermaphrodite gonadal cell types.Paper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
WBPhenotype:0000893Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
RemarkTable 7Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
PenetranceIncomplete19Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005784PATO:0000460Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
Phenotype_assayTemperature20Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
WBPhenotype:0001357Paper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
RemarkMales exhibited gonadal defects.Paper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
WBPhenotype:0001585Paper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
RemarkVas deferens precursor cells undergo divisions that produce daughter cells with little of no size asymmetry, unlike in control animals where these divisions result in daughter cells that are radically different in size.Paper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
WBPhenotype:0001586Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
Remark"Analysis of AC formation gave an unexpected result. Whereas most sys-1 and pop-1 mutants made two or more ACs, as described previously (Miskowski et al. 2001; Siegfried and Kimble 2002), most sys-3, gon-15, gon-16, and many gon-14 mutants had only one AC, although a few had more (Table 6)."Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
PenetranceHigh96Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004522PATO:0000460Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
GO_termGO:0008406PATO:0000460Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
Phenotype_assayTemperature20Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
GenotypesyIs50 [cdh-3::GFP]Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
WBPhenotype:0001968Paper_evidenceWBPaper00026603
WBPaper00035069
Curator_confirmedWBPerson712
WBPerson557
RemarkAnimals have no DTCs and can have extra AC cells.Paper_evidenceWBPaper00026603
Curator_confirmedWBPerson712
PenetranceCompletePaper_evidenceWBPaper00035069
Curator_confirmedWBPerson557
EQ_annotationsAnatomy_termWBbt:0007854PATO:0000460Paper_evidenceWBPaper00026603
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00035069
Curator_confirmedWBPerson557
WBPhenotype:0002211Paper_evidenceWBPaper00035069
WBPaper00006440
Curator_confirmedWBPerson557
WBPerson2987
Remark"The sys-1, sys-3, gon-15, and gon-16 mutants had little effect on phasmid socket cells, but the gon-14(q686) temperature-sensitive mutant raised at restrictive temperature sometimes failed to take up dye into the phasmids (Table 5)."Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
PenetranceIncompletePaper_evidenceWBPaper00035069
Curator_confirmedWBPerson557
Low5Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005425PATO:0000460Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
GO_termGO:0007423PATO:0000460Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
Phenotype_assayTemperature20Paper_evidenceWBPaper00035069
WBPaper00006440
Curator_confirmedWBPerson557
WBPerson2987
Phenotype_not_observedWBPhenotype:0001585Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
Remark"In contrast to the Wnt/MAPK mutants, which eliminate POP-1 asymmetry, sys-1, sys-3, gon-14, gon-15, and gon-16 mutants did not affect POP-1 asymmetry (Figure 5)."Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
WBPhenotype:0002136Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
Remark"Analysis of AC formation gave an unexpected result. Whereas most sys-1 and pop-1 mutants made two or more ACs, as described previously (Miskowski et al. 2001; Siegfried and Kimble 2002), most sys-3, gon-15, gon-16, and many gon-14 mutants had only one AC, although a few had more (Table 6)."Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004522PATO:0000460Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
GO_termGO:0008406PATO:0000460Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
Phenotype_assayTemperature20Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
GenotypesyIs50 [cdh-3::GFP]Paper_evidenceWBPaper00006440
Curator_confirmedWBPerson2987
ReferenceWBPaper00026603
WBPaper00036019
WBPaper00006440
WBPaper00018421
WBPaper00035069
WBPaper00004521
WBPaper00033137
MethodSubstitution_allele