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WormBase Tree Display for Variation: WBVar00241518

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Name Class

WBVar00241518EvidencePaper_evidenceWBPaper00005054
NamePublic_namerh50
Other_nameCE30451:p.Asp355Asn
T13C5.1b.1:c.1063G>A
CE53632:p.Asp334Asn
T13C5.1a.1:c.1108G>A
CE27206:p.Asp370Asn
T13C5.1c.1:c.1000G>A
HGVSgCHROMOSOME_X:g.6199894G>A
Sequence_detailsSMapS_parentSequenceT13C5
Flanking_sequencesagagacctttcaatcatcctaacatgtggaatatgtggacaggaggtatggaaactactg
Mapping_targetT13C5
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004904
WBStrain00004909
WBStrain00008412
WBStrain00033328
WBStrain00047368
LaboratoryNJ
StatusLive
AffectsGeneWBGene00000905
TranscriptT13C5.1c.1 (12)
T13C5.1b.1 (12)
T13C5.1a.1 (12)
InteractorWBInteraction000532940
WBInteraction000532941
WBInteraction000532959
GeneticsInterpolated_map_positionX-3.46105
Mapping_dataIn_multi_point1320
DescriptionPhenotypeWBPhenotype:0000013Paper_evidenceWBPaper00040979
Curator_confirmedWBPerson2987
Remark"Partial reduction of daf-9 function results in animals that bypass the dauer stage yet exhibit abnormal gonadal morphogenesis and migration (Mig; WBPhenotype:0000594) and occasionally aberrant cuticle shedding (Cut; WBPhenotype: 0000077) defects (Figure 2A) [18,19]."Paper_evidenceWBPaper00040979
Curator_confirmedWBPerson2987
WBPhenotype:0000301Paper_evidenceWBPaper00024451
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPerson2987
Remarkdistal tip cells fail to reflexPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Table 1Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
PenetranceHigh89Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006865PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
GO:0008406PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
WBPhenotype:0000690Paper_evidenceWBPaper00040979
Curator_confirmedWBPerson2987
Remark"... the weak loss-of-function allele daf-9(rh50) does not result in Daf-c phenotypes, but in highly penetrant Mig defects (95% +/- 3%) [18]. In these animals, only 10 nM of DA was required to rescue over 90% of the Mig phenotypes (Figure 2C), revealing a 5-fold decrease in the amount of exogenous DA required to promote normal development compared to the stronger daf-9 mutants (dh6, e1406, and m540; Figure 2S). Thus, daf-9(rh50) animals produce sufficient amounts of DA to bypass dauer development but require additional DA to develop into normal adults, consistent with our finding that different levels of DA are required for the two processes."Paper_evidenceWBPaper00040979
Curator_confirmedWBPerson2987
WBPhenotype:0001375Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkfails to express unc-5::lacZPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001739Paper_evidenceWBPaper00045724
Curator_confirmedWBPerson4671
Remarkunable to respond to dietary restrictionPaper_evidenceWBPaper00045724
Curator_confirmedWBPerson4671
WBPhenotype:0001980Paper_evidenceWBPaper00045724
Curator_confirmedWBPerson4671
RemarkLarge amount of germ cells in the transition zone upon dietary restrictionPaper_evidenceWBPaper00045724
Curator_confirmedWBPerson4671
Phenotype_not_observedWBPhenotype:0000012Paper_evidenceWBPaper00040979
Curator_confirmedWBPerson2987
Remark"... the weak loss-of-function allele daf-9(rh50) does not result in Daf-c phenotypes, but in highly penetrant Mig defects (95% +/- 3%) [18]. In these animals, only 10 nM of DA was required to rescue over 90% of the Mig phenotypes (Figure 2C), revealing a 5-fold decrease in the amount of exogenous DA required to promote normal development compared to the stronger daf-9 mutants (dh6, e1406, and m540; Figure 2S). Thus, daf-9(rh50) animals produce sufficient amounts of DA to bypass dauer development but require additional DA to develop into normal adults, consistent with our finding that different levels of DA are required for the two processes."Paper_evidenceWBPaper00040979
Curator_confirmedWBPerson2987
WBPhenotype:0000013Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
EQ_annotationsLife_stageWBls:0000032PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
GO_termGO:0040024PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
WBPhenotype:0000033Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
Remarkdaf-9(rh50) mutants do not exhibit L3 seam cell division timing defectsPaper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005753PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
Life_stageWBls:0000035PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
GO_termGO:0048505PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
WBPhenotype:0000280Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
Remarkdaf-9(rh50) mutants exhibit wild type adult seam cells and alae (Table 1)Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005753PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
GO_termGO:0048505PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
GO:0042335PATO:0000460Paper_evidenceWBPaper00024451
Curator_confirmedWBPerson2987
ReferenceWBPaper00024451
WBPaper00040979
WBPaper00005054
WBPaper00017899
WBPaper00018241
WBPaper00045724
MethodSubstitution_allele