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WormBase Tree Display for Variation: WBVar00249720

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Name Class

WBVar00249720NamePublic_nametm690
Other_nameCE30486:p.Lys441AlafsTer33
CE37743:p.Lys462AlafsTer33
C06G4.2d.1:c.1320_1569del
CE37744:p.Lys416AlafsTer33
C06G4.2a.1:c.1383_1632del
C06G4.2b.1:c.1245_1494del
C06G4.2c.1:c.*1225_*1474del
C06G4.2b.2:c.1245_1494del
C06G4.2a.2:c.1383_1632del
HGVSgCHROMOSOME_III:g.7983968_7984591del
Sequence_detailsSMapS_parentSequenceC06G4
Flanking_sequencesttcaagattgttcggatcatacgaggctcttgcattcttcgaatccgtaatccatgggga
Mapping_targetC06G4
Source_location7CHROMOSOME_III79839677984592Inferred_automaticallyNational_Bioresource_Project
Type_of_mutationDeletion
PCR_producttm690_external
tm690_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryFX
AuthorMitani S
DB_infoDatabaseNational_Bioresource_Projectseq690
NBP_allele
StatusLive
AffectsGeneWBGene00000542
TranscriptC06G4.2d.1 (11)
C06G4.2a.2 (11)
C06G4.2c.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
HGVScC06G4.2c.1:c.*1225_*1474del
cDNA_position1656-1905
Intron_number9/14
Exon_number9-10/15
C06G4.2b.2 (11)
C06G4.2a.1 (11)
C06G4.2b.1 (11)
InteractorWBInteraction000571517
WBInteraction000571522
WBInteraction000571564
IsolationMutagenTMP/UV
GeneticsMapIII
DescriptionPhenotypeWBPhenotype:0002606Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Remark"Likewise, loss of crt-1, cnx-1, itr-1, clp-1, tra-3, asp-3, or asp-4 partially suppressed HBx-induced cell killing (from 50% to 12-32% PLM death; Fig. 2A), indicating that HBx induces cell death in part through the necrotic pathway."Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Phenotype_assayGenotypesmIs98 [Pmec-3::GFP; Pmec-7::HBx]Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000062Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkClassified as homozygous viable by the National Bioresource Project of Japan.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0000072Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComment from Dr. N. Tavernarakis to the National Bioresource Project of Japan: normal body size/shape.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0000415Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComment from Dr. M. Driscoll to the National Bioresource Project of Japan: No effect found on necrotic cell death.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0000531Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComment from Dr. N. Tavernarakis to the National Bioresource Project of Japan: normal development.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0000643Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComment from Dr. N. Tavernarakis to the National Bioresource Project of Japan: normal locomotion.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0000673Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComment from Dr. N. Tavernarakis to the National Bioresource Project of Japan: normal brood size.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
ReferenceWBPaper00041673
Remark7031/7032-7655/7656 (624 bp deletion)
This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use.Paper_evidenceWBPaper00041807
MethodNBP_knockout_allele