WormBase Tree Display for Variation: WBVar00249804

WBVar00249804 Name: Public_name: tm776
    Other_name: C15F1.7a.1:c.135_*115del
    HGVSg: CHROMOSOME_II:g.6972761_6973372del
  Sequence_details: SMap: S_parent: Sequence: C15F1
    Flanking_sequences: tgaaattttgaagaaattttatgtgaaaat ttctgaaaaagaatacaaatgatttaagcg
    Mapping_target: C15F1
    Source_location: 7 CHROMOSOME_II 6972760 6973373 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Deletion
    PCR_product: tm776_external
      tm776_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00007569
      WBStrain00007662
      WBStrain00047284
      WBStrain00047285
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 776
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00196089
      WBGene00004930
    Transcript: C15F1.7b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        cDNA_position: 69-?
        CDS_position: 69-?
        Protein_position: 23-?
        Intron_number: 2-3/3
        Exon_number: 2-4/4
      C15F1.13 VEP_consequence: non_coding_transcript_exon_variant
        VEP_impact: MODIFIER
        cDNA_position: 75-?
        Exon_number: 1/1
      C15F1.7a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,stop_lost,3_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: C15F1.7a.1:c.135_*115del
        cDNA_position: 142-665
        CDS_position: 135-?
        Protein_position: 45-?
        Intron_number: 4-5/6
        Exon_number: 4-7/7
    Interactor: WBInteraction000503939
      WBInteraction000504370
      WBInteraction000586828
  Isolation: Mutagen: TMP/UV
  Genetics: Map: II
  Description: Phenotype: WBPhenotype:0000039 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comment from Dr. S. Yanase: slightly short life span on 20C Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
      WBPhenotype:0000308 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comment from Dr. S. Yanase: dauer arrest abnormal. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
      WBPhenotype:0001171 Paper_evidence: WBPaper00032989
        Curator_confirmed: WBPerson708
        Remark: e.g. Figure 3. (A) and (B): sod-1 deletion strains's lifespans shortened than wild-type N2, however, transgenic strains's lifespans recovered to the wild-type level. Paper_evidence: WBPaper00032989
            Curator_confirmed: WBPerson708
        Rescued_by_transgene: WBTransgene00005543
        Phenotype_assay: Control_strain: WBStrain00000001 Paper_evidence: WBPaper00032989
              Curator_confirmed: WBPerson708
      WBPhenotype:0001418 Paper_evidence: WBPaper00044578
        Curator_confirmed: WBPerson12259
        Remark: Figure 3A Paper_evidence: WBPaper00044578
            Curator_confirmed: WBPerson12259
      WBPhenotype:0002382 Paper_evidence: WBPaper00048427
        Curator_confirmed: WBPerson11689
        Phenotype_assay: Genotype: dvIs19 [Pgst-4::GFP::NLS] Paper_evidence: WBPaper00048427
              Curator_confirmed: WBPerson11689
    Phenotype_not_observed: WBPhenotype:0000062 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as homozygous viable by the National Bioresource Project of Japan. Dr. S. Hekimi: PLoS Genetics 5, e1000361 (2009).Dr. O. Hobert: Nat. Neurosci. 11, 894 (2008). Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
      WBPhenotype:0000308 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comment from Dr. G. Ruvkun to the National Bioresource Center of Japan: no effect on dauer arrest. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
      WBPhenotype:0001620 Paper_evidence: WBPaper00066254
        Curator_confirmed: WBPerson557
        Remark: Oxidative stress, as measured by an Intestine-specific fluorescent marker (rxRFP), is not elevated in the sod-1(tm776) mutant compared to controls. Paper_evidence: WBPaper00066254
            Curator_confirmed: WBPerson557
      WBPhenotype:0001739 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comment from Dr. M. Driscoll: no significant effects on aging. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
  Reference: WBPaper00032989
    WBPaper00044578
    WBPaper00048427
    WBPaper00066254
  Remark: 17154/17155-17766/17767 (612 bp deletion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele