WormBase Tree Display for Variation: WBVar00250054

WBVar00250054 Name: Public_name: tm1034
    Other_name: Y49E10.11a.2:c.918_935-11delinsT
      Y49E10.11a.1:c.918_935-11delinsT
      Y49E10.11c.1:c.918_935-11delinsT
      Y49E10.11b.1:c.918_935-11delinsT
    HGVSg: CHROMOSOME_III:g.12414983_12415579delinsA
  Sequence_details: SMap: S_parent: Sequence: Y49E10
    Flanking_sequences: tgagccttttggatcgtgttctgcaaattt caagcctgtggaatattatttcccctccaa
    Mapping_target: Y49E10
    Source_location: 7 CHROMOSOME_III 12414982 12415580 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Insertion: A
      Deletion
    PCR_product: tm1034_external
      tm1034_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 1034
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00013034
    Transcript: Y49E10.11c.1 VEP_consequence: splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: Y49E10.11c.1:c.918_935-11delinsT
        cDNA_position: 1073-?
        CDS_position: 918-?
        Protein_position: 306-?
        Intron_number: 8/20
        Exon_number: 8/21
      Y49E10.11b.1 VEP_consequence: splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: Y49E10.11b.1:c.918_935-11delinsT
        cDNA_position: 918-?
        CDS_position: 918-?
        Protein_position: 306-?
        Intron_number: 6/15
        Exon_number: 6/16
      Y49E10.11a.2 VEP_consequence: splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: Y49E10.11a.2:c.918_935-11delinsT
        cDNA_position: 985-?
        CDS_position: 918-?
        Protein_position: 306-?
        Intron_number: 7/18
        Exon_number: 7/19
      Y49E10.11a.1 VEP_consequence: splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: Y49E10.11a.1:c.918_935-11delinsT
        cDNA_position: 1221-?
        CDS_position: 918-?
        Protein_position: 306-?
        Intron_number: 8/19
        Exon_number: 8/20
    Interactor: WBInteraction000050586
  Isolation: Mutagen: TMP/UV
  Genetics: Map: III
  Description: Phenotype: WBPhenotype:0001428 Paper_evidence: WBPaper00032283
        Curator_confirmed: WBPerson712
        Remark: Animals raised at 25 C displayed the same vacuolation phenotype as tat-1(kr15). Paper_evidence: WBPaper00032283
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005772 PATO:0000460 Paper_evidence: WBPaper00032283
                Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00032283
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 15, 20, 25 Paper_evidence: WBPaper00032283
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000030 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comment from M. Han to the National Bioresource Project of Japan: normal growth rate. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
      WBPhenotype:0000062 Paper_evidence: WBPaper00032283
        Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as homozygous viable by the National Bioresource Project of Japan. Comment to the NBP from Dr. S. Tuck: Traffick 10, 88 (2009). Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
          Worms are viable. Paper_evidence: WBPaper00032283
            Curator_confirmed: WBPerson712
      WBPhenotype:0000688 Paper_evidence: WBPaper00032283
        Curator_confirmed: WBPerson712
  Reference: WBPaper00032283
  Remark: 47578/47579-A-48175/48176 (597 bp deletion + 1 bp insertion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele