WormBase Tree Display for Variation: WBVar00250961

WBVar00250961 Evidence: Paper_evidence: WBPaper00061133
  Name: Public_name: tm2001
    Other_name: ZK1251.2b.1:c.33+65_89delinsT
    HGVSg: CHROMOSOME_IV:g.9682366_9682729delinsA
  Sequence_details: SMap: S_parent: Sequence: ZK1251
    Flanking_sequences: tgatcatttaaggactccagtgaaaaagga aataataatcagtcgatcagactgacaggt
    Mapping_target: ZK1251
    Source_location: 7 CHROMOSOME_IV 9682365 9682730 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Insertion: A
      Deletion
    PCR_product: tm2001_external
      tm2001_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00048365
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 2001
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00002090
    Transcript: ZK1251.2b.1 VEP_consequence: splice_acceptor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: ZK1251.2b.1:c.33+65_89delinsT
        cDNA_position: ?-108
        CDS_position: ?-89
        Protein_position: ?-30
        Intron_number: 2/4
        Exon_number: 3/5
      ZK1251.2a.1 VEP_consequence: coding_sequence_variant,5_prime_UTR_variant
        VEP_impact: MODIFIER
        cDNA_position: ?-56
        CDS_position: ?-56
        Protein_position: ?-19
        Exon_number: 1/3
    Interactor: WBInteraction000543195
      WBInteraction000543219
  Isolation: Mutagen: TMP/UV
  Genetics: Map: IV
  Description: Phenotype: WBPhenotype:0000061 Paper_evidence: WBPaper00031230
        Curator_confirmed: WBPerson712
        Remark: Mean lifespan is increased (17.4 0.4 (n = 99/153), P < 0.0001) compared to N2 (14.3 0.3 (n = 176/215; events/total)). Paper_evidence: WBPaper00031230
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Strain was outcrossed 3 times to N2 before testing. Paper_evidence: WBPaper00031230
              Curator_confirmed: WBPerson712
          Temperature: 20C Paper_evidence: WBPaper00031230
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000062 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as homozygous viable by the National Bioresource Project of Japan. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
      WBPhenotype:0000643 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Comments to the National Bioresource Project of Japan: Dr. P.W. Sternberg: normal locomotion. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
            Laboratory_evidence: FX
  Reference: WBPaper00031230
    WBPaper00061133
  Remark: 11135/11136-A-11499/11500 (364 bp deletion + 1 bp insertion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele