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WormBase Tree Display for Variation: WBVar00251261

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Name Class

WBVar00251261NamePublic_nametm2366
Other_nameCE36215:p.Arg5_Ter173delinsSer
W06H3.1.1:c.13_517delinsT
HGVSgCHROMOSOME_V:g.16789391_16789990delinsT
Sequence_detailsSMapS_parentSequenceW06H3
Flanking_sequencesatttttaattcaaaagtcatgcgtggaagtgattcgagctattgagcatcacgttcagac
Mapping_targetW06H3
Source_location7CHROMOSOME_V1678939016789992Inferred_automaticallyNational_Bioresource_Project
Type_of_mutationInsertionTC
Deletion
PCR_producttm2366_external
tm2366_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryFX
AuthorMitani S
DB_infoDatabaseNational_Bioresource_Projectseq2366
NBP_allele
StatusLive
AffectsGeneWBGene00012315
TranscriptW06H3.1.1 (11)
InteractorWBInteraction000501298
WBInteraction000501299
WBInteraction000501300
IsolationMutagenTMP/UV
GeneticsMapV
DescriptionPhenotypeWBPhenotype:0000030Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComments to the National Bioresource Project of Japan: Dr. A. van der Bliek: Gro.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0000229Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComments to the National Bioresource Project of Japan: Dr. A. van der Bliek: Sma (~20%).Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0000673Paper_evidenceWBPaper00038057
Curator_confirmedWBPerson712
RemarkThe immt-2(tm2366) mutants have smaller brood sizes than wild-type or immt-1(tm1730) animals.Paper_evidenceWBPaper00038057
Curator_confirmedWBPerson712
WBPhenotype:0001401Paper_evidenceWBPaper00038057
Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComments to the National Bioresource Project of Japan: Dr. A. van der Bliek: Connected mitochondria in muscle.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
The immt-2(tm2366) deletion severely disrupts the morphologies of mitochondria in C. elegans hypodermal and muscle cells. immt-2 defects give rise to mitochondria that are generally thinner and more connected than mitochondria in wild-type cells or cells with immt-1 defects.Paper_evidenceWBPaper00038057
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0003675PATO:0000460Paper_evidenceWBPaper00038057
Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBbt:0007846PATO:0000460Paper_evidenceWBPaper00038057
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000062Person_evidenceWBPerson7743
Curator_confirmedWBPerson48
RemarkClassified as homozygous viable by the National Bioresource Project of Japan.Person_evidenceWBPerson7743
Curator_confirmedWBPerson48
Laboratory_evidenceFX
WBPhenotype:0000643Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComments to the National Bioresource Project of Japan: Dr. A. van der Bliek: normal locomotion.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0000688Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComments to the National Bioresource Project of Japan: Dr. A. van der Bliek: fertile.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0001400Paper_evidenceWBPaper00038057
Curator_confirmedWBPerson712
RemarkMOMA-1 protein levels were not significantly altered in these worms.Paper_evidenceWBPaper00038057
Curator_confirmedWBPerson712
ReferenceWBPaper00038057
WBPaper00065829
Remark2406/2407-TC-3007/3008 (601 bp deletion + 2 bp insertion)
This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use.Paper_evidenceWBPaper00041807
MethodNBP_knockout_allele