WormBase Tree Display for Variation: WBVar00251565

WBVar00251565 Name: Public_name: tm2721
    Other_name: CE37072:p.Arg425_Tyr527delinsLysAsn
      Y74C10AR.3a.1:c.1273_1579delinsAAAA
    HGVSg: CHROMOSOME_I:g.2475108_2475414delinsTTTT
  Sequence_details: SMap: S_parent: Sequence: Y74C10AM
    Flanking_sequences: acgctgacggccttccatacgccaaattat tttcgcgtcggcagcctccacgatttttgg
    Mapping_target: Y74C10AM
    Source_location: 7 CHROMOSOME_I 2475107 2475415 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Insertion: TTTT
      Deletion
    PCR_product: tm2721_external
      tm2721_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 2721
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00022281
    Transcript: Y74C10AR.3a.1 VEP_consequence: protein_altering_variant
        VEP_impact: MODERATE
        HGVSc: Y74C10AR.3a.1:c.1273_1579delinsAAAA
        HGVSp: CE37072:p.Arg425_Tyr527delinsLysAsn
        cDNA_position: 1282-1588
        CDS_position: 1273-1579
        Protein_position: 425-527
        Exon_number: 7/10
        Codon_change: CGGCTCGAAATTGTCGATAACGATATTAGTTTGAAATTTGAAAATGTGCATTTTGGATATCTCCCCGAAAAGCCGATTTTAAAGGGATTAGATTTGGAAATTCCGGTCGGAAAAAAAGTTGCAATCGTCGGTGGAAGTGGTTCGGGAAAATCGACAATTGTTCGGCTTCTCTATAGACTTTATGACACAGAAAGTGGAAATGTACGAATTAATGGACTAGAAACTCGAGATTTAACACTGGATTCACTCCGGCAAAGTATTAGTATTGTTCCACAGGATTCCGTACTTTTCCATGATACAATTTTCTat/AAAAat
        Amino_acid_change: RLEIVDNDISLKFENVHFGYLPEKPILKGLDLEIPVGKKVAIVGGSGSGKSTIVRLLYRLYDTESGNVRINGLETRDLTLDSLRQSISIVPQDSVLFHDTIFY/KN
  Isolation: Mutagen: TMP/UV
  Genetics: Map: I
  Description: Phenotype: WBPhenotype:0000062 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson48
        Remark: Classified as lethal OR sterile by the National Bioresource Project of Japan. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson48
            Laboratory_evidence: FX
      WBPhenotype:0000688 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson48
        Remark: Classified as lethal OR sterile by the National Bioresource Project of Japan. Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson48
            Laboratory_evidence: FX
  Disease_info: Models_disease: DOID:0050554
    Models_disease_in_annotation: WBDOannot00000009
  Remark: [Y74C10AL] 11227/11228-TTTT- [Y74C10AL] 11534/11535 (307 bp deletion + 4 bp insertion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
    Old Mapping_target Y74C10AL updated based on the VEP analysis pipeline to Y74C10AM.
  Method: NBP_knockout_allele