WormBase Tree Display for Variation: WBVar00251919

WBVar00251919 Name: Public_name: tm3146
    Other_name: CE46622:p.Trp278_Ile422delinsTer
      F25H8.3a.2:c.831_1264delinsATGAATTGGGTCATGTG
      F25H8.3a.1:c.831_1264delinsATGAATTGGGTCATGTG
      F25H8.3b.1:c.831_1264delinsATGAATTGGGTCATGTG
      CE42668:p.Trp278_Ile422delinsTer
    HGVSg: CHROMOSOME_IV:g.9943235_9943668delinsCACATGACCCAATTCAT
  Sequence_details: SMap: S_parent: Sequence: T13H10
    Flanking_sequences: tcgaaaacacatgacccaattcatgagcaa gagttggcagctcttcgggatcttgctttg
    Mapping_target: T13H10
    Source_location: 7 CHROMOSOME_IV 9943234 9943669 Inferred_automatically: National_Bioresource_Project
    Type_of_mutation: Insertion: CACATGACCCAATTCAT
      Deletion
    PCR_product: tm3146_external
      tm3146_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: FX
    Author: Mitani S
    DB_info: Database: National_Bioresource_Project seq 3146
    NBP_allele
    Status: Live
  Affects: Gene: WBGene00001650
    Transcript: F25H8.3a.1 VEP_consequence: stop_gained,protein_altering_variant
        VEP_impact: HIGH
        HGVSc: F25H8.3a.1:c.831_1264delinsATGAATTGGGTCATGTG
        HGVSp: CE42668:p.Trp278_Ile422delinsTer
        cDNA_position: 1335-1768
        CDS_position: 831-1264
        Protein_position: 277-422
        Exon_number: 11/32
        Codon_change: tcTTGGGATCACTATGTTGAAGTCCTTGTGGTGGCGGATACAAAAATGTACGAATATCACGGAAGATCTCTTGAAGACTACGTTCTCACTCTCTTCTCCACAGTTGCCTCCATCTATCGTCACCAATCCCTTCGTGCATCTATCAATGTCGTTGTTGTCAAGTTGATCGTTTTGAAAACGGAAAACGCTGGACCACGAATCACTCAGAACGCTCAACAAACACTTCAAGATTTCTGTAGATGGCAGCAGTATTACAATGATCCAGATGATTCGAGTGTCCAACATCATGACGTTGCAATCCTTTTGACGCGTAAAGATATTTGTCGATCACAAGGAAAATGCGATACACTTGGACTTGCTGAACTTGGAACAATGTGTGATATGCAAAAAAGTTGTGCAATCATAGAAGACAATGGATTGAGTGCTGCATTCACAAtt/tcATGAATTGGGTCATGTGtt
        Amino_acid_change: SWDHYVEVLVVADTKMYEYHGRSLEDYVLTLFSTVASIYRHQSLRASINVVVVKLIVLKTENAGPRITQNAQQTLQDFCRWQQYYNDPDDSSVQHHDVAILLTRKDICRSQGKCDTLGLAELGTMCDMQKSCAIIEDNGLSAAFTI/S*IGSCV
      F25H8.3a.2 VEP_consequence: stop_gained,protein_altering_variant
        VEP_impact: HIGH
        HGVSc: F25H8.3a.2:c.831_1264delinsATGAATTGGGTCATGTG
        HGVSp: CE42668:p.Trp278_Ile422delinsTer
        cDNA_position: 1221-1654
        CDS_position: 831-1264
        Protein_position: 277-422
        Exon_number: 9/30
        Codon_change: tcTTGGGATCACTATGTTGAAGTCCTTGTGGTGGCGGATACAAAAATGTACGAATATCACGGAAGATCTCTTGAAGACTACGTTCTCACTCTCTTCTCCACAGTTGCCTCCATCTATCGTCACCAATCCCTTCGTGCATCTATCAATGTCGTTGTTGTCAAGTTGATCGTTTTGAAAACGGAAAACGCTGGACCACGAATCACTCAGAACGCTCAACAAACACTTCAAGATTTCTGTAGATGGCAGCAGTATTACAATGATCCAGATGATTCGAGTGTCCAACATCATGACGTTGCAATCCTTTTGACGCGTAAAGATATTTGTCGATCACAAGGAAAATGCGATACACTTGGACTTGCTGAACTTGGAACAATGTGTGATATGCAAAAAAGTTGTGCAATCATAGAAGACAATGGATTGAGTGCTGCATTCACAAtt/tcATGAATTGGGTCATGTGtt
        Amino_acid_change: SWDHYVEVLVVADTKMYEYHGRSLEDYVLTLFSTVASIYRHQSLRASINVVVVKLIVLKTENAGPRITQNAQQTLQDFCRWQQYYNDPDDSSVQHHDVAILLTRKDICRSQGKCDTLGLAELGTMCDMQKSCAIIEDNGLSAAFTI/S*IGSCV
      F25H8.3b.1 VEP_consequence: stop_gained,protein_altering_variant
        VEP_impact: HIGH
        HGVSc: F25H8.3b.1:c.831_1264delinsATGAATTGGGTCATGTG
        HGVSp: CE46622:p.Trp278_Ile422delinsTer
        cDNA_position: 831-1264
        CDS_position: 831-1264
        Protein_position: 277-422
        Exon_number: 7/28
        Codon_change: tcTTGGGATCACTATGTTGAAGTCCTTGTGGTGGCGGATACAAAAATGTACGAATATCACGGAAGATCTCTTGAAGACTACGTTCTCACTCTCTTCTCCACAGTTGCCTCCATCTATCGTCACCAATCCCTTCGTGCATCTATCAATGTCGTTGTTGTCAAGTTGATCGTTTTGAAAACGGAAAACGCTGGACCACGAATCACTCAGAACGCTCAACAAACACTTCAAGATTTCTGTAGATGGCAGCAGTATTACAATGATCCAGATGATTCGAGTGTCCAACATCATGACGTTGCAATCCTTTTGACGCGTAAAGATATTTGTCGATCACAAGGAAAATGCGATACACTTGGACTTGCTGAACTTGGAACAATGTGTGATATGCAAAAAAGTTGTGCAATCATAGAAGACAATGGATTGAGTGCTGCATTCACAAtt/tcATGAATTGGGTCATGTGtt
        Amino_acid_change: SWDHYVEVLVVADTKMYEYHGRSLEDYVLTLFSTVASIYRHQSLRASINVVVVKLIVLKTENAGPRITQNAQQTLQDFCRWQQYYNDPDDSSVQHHDVAILLTRKDICRSQGKCDTLGLAELGTMCDMQKSCAIIEDNGLSAAFTI/S*IGSCV
    Interactor: WBInteraction000534755
      WBInteraction000534757
      WBInteraction000534758
      WBInteraction000534759
      WBInteraction000534760
  Isolation: Mutagen: TMP/UV
  Genetics: Map: IV
  Description: Phenotype: WBPhenotype:0000061 Paper_evidence: WBPaper00048391
        Curator_confirmed: WBPerson426
      WBPhenotype:0000062 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as lethal OR sterile by the National Bioresource Project of Japan Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
      WBPhenotype:0000436 Paper_evidence: WBPaper00048391
        Curator_confirmed: WBPerson426
        Remark: DAF-16 nuclear localization Paper_evidence: WBPaper00048391
            Curator_confirmed: WBPerson426
      WBPhenotype:0000688 Person_evidence: WBPerson7743
        Curator_confirmed: WBPerson712
        Remark: Classified as lethal OR sterile by the National Bioresource Project of Japan Person_evidence: WBPerson7743
            Curator_confirmed: WBPerson712
      WBPhenotype:0000724 Paper_evidence: WBPaper00048391
        Curator_confirmed: WBPerson426
      WBPhenotype:0001719 Paper_evidence: WBPaper00040883
        Curator_confirmed: WBPerson426
  Reference: WBPaper00040883
    WBPaper00048391
  Remark: [T13H10] 4793/4794-CACATGACCCAATTCAT-[T13H10] 5227/5228 (434 bp deletion + 17 bp insertion)
    This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence: WBPaper00041807
  Method: NBP_knockout_allele