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WormBase Tree Display for Variation: WBVar00252673

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Name Class

WBVar00252673NamePublic_nametm4144
HGVSgCHROMOSOME_IV:g.9680302_9680803del
Sequence_detailsSMapS_parentSequenceZK1251
Flanking_sequencestaacactatttctttgaatatcttccttgatataagtctttttatgcttaaaaagtgaga
Mapping_targetZK1251
Source_location7CHROMOSOME_IV96803019680804Inferred_automaticallyNational_Bioresource_Project
Type_of_mutationDeletion
PCR_producttm4144_external
tm4144_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryFX
AuthorMitani S
DB_infoDatabaseNational_Bioresource_Projectseq4144
NBP_allele
StatusLive
AffectsGeneWBGene00002091
TranscriptZK1251.11a.1VEP_consequencetranscript_ablation
VEP_impactHIGH
Intron_number2/3
Exon_number1-4/4
Interactor (42)
IsolationMutagenTMP/UV
GeneticsMapIV
DescriptionPhenotypeWBPhenotype:0000136Paper_evidenceWBPaper00042184
Curator_confirmedWBPerson2987
Remark"We examined endogenous ins-7 expression in an ins-8 mutant and vice versa and found that while loss of ins-8 did not result in a change in ins-7 expression, loss of ins-7 resulted in a ~15-fold increase in ins-8 expression (Fig 6C)."Paper_evidenceWBPaper00042184
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000012Paper_evidenceWBPaper00042184
Curator_confirmedWBPerson2987
Remark"We found that neither deletions in 12 insulins nor knockdown of any of the 40 insulins results in dauers (Fig 1A; Supplemental Table S2)."Paper_evidenceWBPaper00042184
Curator_confirmedWBPerson2987
WBPhenotype:0000013Paper_evidenceWBPaper00042184
Curator_confirmedWBPerson2987
Remark"After dauer-inducing conditions, all mutants analyzed were capable of forming dauers, indicating that they are not dauer defective (Fig 1B). "Paper_evidenceWBPaper00042184
Curator_confirmedWBPerson2987
WBPhenotype:0000039Paper_evidenceWBPaper00042184
Curator_confirmedWBPerson2987
RemarkFigure S7Paper_evidenceWBPaper00042184
Curator_confirmedWBPerson2987
WBPhenotype:0000062Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkClassified as homozygous viable by the National Bioresource Project of JapanPerson_evidenceWBPerson7743
Curator_confirmedWBPerson712
ReferenceWBPaper00042184
Remark9071/9072-9573/9574 (502 bp deletion)
This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use.Paper_evidenceWBPaper00041807
MethodNBP_knockout_allele