WormBase Tree Display for Variation: WBVar00266506

WBVar00266506 Name: Public_name: u38
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026624
      WBStrain00035030
    Laboratory: TU
    Status: Live
  Linked_to: WBVar00266507
  Affects: Gene: WBGene00000950
    Interactor: WBInteraction000517985
      WBInteraction000569201
  Genetics: Mapping_data: In_2_point: 1828
      In_multi_point: 789
        1202
        1203
        1337
        3241
        3375
  Description: Phenotype: WBPhenotype:0000179 Paper_evidence: WBPaper00001299
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
          WBPerson95
        Remark: PVC interneurons degenerate at L1/L2, certain other neurons die at hatching (some IL1, also probably AVG) or L4 moult (probably AVD). Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
          Degeneration of PVC, AVD, AVG, and IL1 neurons Paper_evidence: WBPaper00001299
            Curator_confirmed: WBPerson95
        Dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005840 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
              PATO:0000639 Paper_evidence: WBPaper00001299
                Curator_confirmed: WBPerson95
            WBbt:0005119 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
              PATO:0000639 Paper_evidence: WBPaper00001299
                Curator_confirmed: WBPerson95
            WBbt:0006818 PATO:0000639 Paper_evidence: WBPaper00001299
                Curator_confirmed: WBPerson95
            WBbt:0003850 PATO:0000639 Paper_evidence: WBPaper00001299
                Curator_confirmed: WBPerson95
        Temperature_sensitive: Heat_sensitive: Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Ease_of_scoring: ES2_Difficult_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000316 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: touch-insensitive and prod-insensitive only in tail. PVC interneurons degenerate at L1/L2, certain other neurons die at hatching (some IL1, also probably AVG) or L4 moult (probably AVD). ES2 Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000729 Paper_evidence: WBPaper00002711
        Curator_confirmed: WBPerson233
        Remark: Figure 8 shows progressive necrotic changes in both a anal depressor muscle (panels B, C) and in a neuron (panel A) when u38 was overexpressed during larval development Paper_evidence: WBPaper00002711
            Curator_confirmed: WBPerson233
        EQ_annotations: Anatomy_term: WBbt:0004292 PATO:0000460 Paper_evidence: WBPaper00002711
                Curator_confirmed: WBPerson233
      WBPhenotype:0001221 Paper_evidence: WBPaper00003408
        Curator_confirmed: WBPerson557
        Variation_effect: Gain_of_function_undetermined_type: Paper_evidence: WBPaper00003408
            Curator_confirmed: WBPerson557
      WBPhenotype:0002535 Paper_evidence: WBPaper00003408
        Curator_confirmed: WBPerson557
        Remark: ASH degeneration was assessed by dye filling with DiO. Paper_evidence: WBPaper00003408
            Curator_confirmed: WBPerson557
    Phenotype_not_observed: WBPhenotype:0000306 Paper_evidence: WBPaper00031997
        Curator_confirmed: WBPerson712
        Remark: lag-2::GFP was expressed at the same levels as in dauer larvae induced by dauer pheromone, starvation or by Daf-c mutations in the three parallel pathways. Paper_evidence: WBPaper00031997
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005118 PATO:0000460 Paper_evidence: WBPaper00031997
                Curator_confirmed: WBPerson712
          Life_stage: WBls:0000032 PATO:0000460 Paper_evidence: WBPaper00031997
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: qIs56 [lag-2::GFP , unc-119(+)] Paper_evidence: WBPaper00031997
              Curator_confirmed: WBPerson712
  Disease_info: Models_disease: DOID:1289
      DOID:14452
    Models_disease_in_annotation: WBDOannot00000326
      WBDOannot00000327
      WBDOannot00000606
      WBDOannot00000607
      WBDOannot00000608
  Reference (22)
  Method: Allele