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WormBase Tree Display for Variation: WBVar00275126

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Name Class

WBVar00275126EvidencePaper_evidenceWBPaper00005233
NamePublic_namewa23
Other_nameCE48384:p.Gly322Arg
W08D2.4a.1:c.1267G>A
W08D2.4d.1:c.964G>A
CE25153:p.Gly423Arg
CE45719:p.Gly165Arg
W08D2.4c.1:c.169G>A
W08D2.4b.1:c.493G>A
CE45812:p.Gly57Arg
HGVSgCHROMOSOME_IV:g.9805934G>A
Sequence_detailsSMapS_parentSequenceW08D2
Flanking_sequencescttccttacctcgtcgatgactactttgacgatatgcaatgaatttgcaacaattgaaaa
Mapping_targetW08D2
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00005233
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryBX
StatusLive
AffectsGeneWBGene00001395
TranscriptW08D2.4d.1 (12)
W08D2.4a.1 (12)
W08D2.4b.1 (12)
W08D2.4c.1 (12)
GeneticsInterpolated_map_positionIV4.42145
DescriptionPhenotypeWBPhenotype:0000031Paper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
RemarkAlthough fat-3 homozygotes are viable and fertile, they grow slowly, move sluggishly, and have a reduced brood size. In growth comparisons, authors found that after 3 days of growth at 20 degrees Celsius, staged embryos produced by fat-3 homozygous mothers had developed to L4 larval stage, whereas similar stage WT embryos had reached adulthood and were beginning to lay eggs (Fig. 3 A and D). The fat-3 animals required an additional day of development before commencing egg laying.Paper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
WBPhenotype:0000138Paper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
Remarkfat-3 mutants displayed a modest increase in fatty acids 18:2n6 (9.1 vs. 5.4% in WT) and 18:3n3 (2 vs. 0.2% in WT). Homozygotes segregating from this population displayed a striking fatty acid composition, with only 1.0% 20:2n6 and 1.6% 20:3n3 and no other detectable C20 fatty acids (Fig. 3D, Table 1). The 18:2n6 increased to 12.7% and the 18:3n3 accumulated to 11.0%.Paper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
WBPhenotype:0000154Paper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
RemarkAlthough fat-3 homozygotes are viable and fertile, they grow slowly, move sluggishly, and have a reduced brood size.Paper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
WBPhenotype:0000646Paper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
RemarkAlthough fat-3 homozygotes are viable and fertile, they grow slowly, move sluggishly, and have a reduced brood size.Paper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
WBPhenotype:0001418Paper_evidenceWBPaper00044578
Curator_confirmedWBPerson12259
RemarkFigure 4BPaper_evidenceWBPaper00044578
Curator_confirmedWBPerson12259
Phenotype_not_observedWBPhenotype:0000062Paper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
Remarkfat-3 homozygotes are viable.Paper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
WBPhenotype:0000688Paper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
Remarkfat-3 homozygotes are fertilePaper_evidenceWBPaper00005233
Curator_confirmedWBPerson2987
ReferenceWBPaper00005233
WBPaper00044578
MethodSubstitution_allele