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WormBase Tree Display for Variation: WBVar00275385

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Name Class

WBVar00275385EvidencePaper_evidenceWBPaper00028852
NamePublic_nameye4
Other_nameC53B4.7e.1:c.680G>A
CE40447:p.Gly215Glu
CE27116:p.Gly217Glu
CE23608:p.Gly201Glu
CE40448:p.Gly227Glu
C53B4.7c.1:c.602G>A
C53B4.7d.1:c.644G>A
C53B4.7b.1:c.695G>A
CE27117:p.Gly232Glu
C53B4.7a.1:c.650G>A
HGVSgCHROMOSOME_IV:g.8989585G>A
Sequence_detailsSMapS_parentSequenceC53B4
Flanking_sequencesgtgaagcctacaatatgtttgcttgcaatgaattttgttcaaccatgagagtccaagaag
Mapping_targetC53B4
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00028852
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00008570
LaboratoryHY
StatusLive
AffectsGeneWBGene00000266
TranscriptC53B4.7e.1 (12)
C53B4.7a.1 (12)
C53B4.7b.1 (12)
C53B4.7d.1 (12)
C53B4.7c.1 (12)
GeneticsInterpolated_map_positionIV4.00029
DescriptionPhenotypeWBPhenotype:0000154Paper_evidenceWBPaper00028852
Curator_confirmedWBPerson557
Phenotype_assayTemperature25Paper_evidenceWBPaper00028852
Curator_confirmedWBPerson557
WBPhenotype:0000673Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals have robust but lower than wild-type brood sizes.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
WBPhenotype:0001507Paper_evidenceWBPaper00028852
Curator_confirmedWBPerson557
Remarkbre-1(ye4) animals are resistant to Cry5B.Paper_evidenceWBPaper00028852
Curator_confirmedWBPerson557
Affected_byMoleculeWBMol:00005329Paper_evidenceWBPaper00028852
Curator_confirmedWBPerson557
WBPhenotype:0002035Paper_evidenceWBPaper00041118
Curator_confirmedWBPerson9999
Remarkresistant to Coprinopsis cinerea fruiting body lectin CCL2Paper_evidenceWBPaper00041118
Curator_confirmedWBPerson9999
Affected_byMoleculeWBMol:00007869Paper_evidenceWBPaper00041118
Curator_confirmedWBPerson9999
WBPhenotype:0002036Paper_evidenceWBPaper00039883
Curator_confirmedWBPerson9999
Remarksusceptible to fruiting body lectin Marasmius oreades agglutinin (MOA, a Galα1,3Gal/GalNAc-specific lectin). Mutations in bre-3, bre-4 or bre-5 confer resistancePaper_evidenceWBPaper00039883
Curator_confirmedWBPerson9999
Affected_byMoleculeWBMol:00007870Paper_evidenceWBPaper00039883
Curator_confirmedWBPerson9999
WBPhenotype:0002060Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkProduces a brood when grown in the presence of Bt toxin Cry5B. The intestines of mutants fed Bt-produced toxin have intestinal morphology often indistinguishable from that of healthy wild-type intestine not exposed to toxin. Mutants are resistant to Cry5B-induced lethality. Unlike toxin-exposed wild-type animals, toxin-exposed mutants show only a modest reduction in fertility. Similar resistance is observed for animals exposed to E. coli produced Cry5B toxin. Mutants are similarly sensitive to Cry6A.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00005329Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000072Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals appear morphologically normal.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
WBPhenotype:0000517Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals behave similarly to wild-type.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
WBPhenotype:0000676Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals develop from embryos to adults at the normal wild-type rate.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
ReferenceWBPaper00039883
WBPaper00041118
WBPaper00004264
WBPaper00028852
MethodSubstitution_allele