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WormBase Tree Display for Variation: WBVar00275390

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Name Class

WBVar00275390EvidencePaper_evidenceWBPaper00006229
NamePublic_nameye13
Other_nameY73E7A.7a.1:c.845delinsA
CE49566:p.Trp117Ter
CE26412:p.Trp282Ter
Y73E7A.7a.2:c.845delinsA
Y73E7A.7b.1:c.350delinsA
HGVSgCHROMOSOME_I:g.1622529delinsT
Sequence_detailsSMapS_parentSequenceY73E7A
Flanking_sequencesatcaatggattttcgaatgatttttggggttggcggagaggacgacgatttggcgacgaga
Mapping_targetY73E7A
Type_of_mutationSubstitutionggrrPaper_evidenceWBPaper00006229
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryHY
StatusLive
AffectsGeneWBGene00000269
TranscriptY73E7A.7a.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScY73E7A.7a.1:c.845delinsA
HGVSpCE26412:p.Trp282Ter
cDNA_position943-944
CDS_position845-846
Protein_position282
Exon_number7/9
Codon_changetGG/tAG
Amino_acid_changeW/*
Y73E7A.7b.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScY73E7A.7b.1:c.350delinsA
HGVSpCE49566:p.Trp117Ter
cDNA_position361-362
CDS_position350-351
Protein_position117
Exon_number4/6
Codon_changetGG/tAG
Amino_acid_changeW/*
Y73E7A.7a.2VEP_consequencestop_gained
VEP_impactHIGH
HGVScY73E7A.7a.2:c.845delinsA
HGVSpCE26412:p.Trp282Ter
cDNA_position879-880
CDS_position845-846
Protein_position282
Exon_number6/8
Codon_changetGG/tAG
Amino_acid_changeW/*
GeneticsInterpolated_map_positionI-13.697
DescriptionPhenotypeWBPhenotype:0001524Paper_evidenceWBPaper00051118
Curator_confirmedWBPerson38423
RemarkLethargus duration increased by 7%; total sleep increased by 14%; Bout duration increased by 4% (Table 2A)Paper_evidenceWBPaper00051118
Curator_confirmedWBPerson38423
WBPhenotype:0002060Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkProduces a brood when grown in the presence of Bt toxin Cry5B. The intestines of mutants fed Bt-produced toxin have intestinal morphology often indistinguishable from that of healthy wild-type intestine not exposed to toxin. Mutants are resistant to Cry5B-induced lethality. Unlike toxin-exposed wild-type animals, toxin-exposed mutants show only a modest reduction in fertility. Similar resistance is observed for animals exposed to E. coli produced Cry5B toxin. Mutants are similarly sensitive to Cry6A.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00005329Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000072Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals appear morphologically normal.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
WBPhenotype:0000154Paper_evidenceWBPaper00028852
Curator_confirmedWBPerson557
Phenotype_assayTemperature25Paper_evidenceWBPaper00028852
Curator_confirmedWBPerson557
WBPhenotype:0000517Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals behave similarly to wild-type.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
WBPhenotype:0000673Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals have wild-type brood sizes.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
WBPhenotype:0000676Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
RemarkAnimals develop from embryos to adults at the normal wild-type rate.Paper_evidenceWBPaper00004264
Curator_confirmedWBPerson712
ReferenceWBPaper00006229
WBPaper00004264
WBPaper00028852
WBPaper00051118
MethodSubstitution_allele