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WormBase Tree Display for Variation: WBVar00275446

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Name Class

WBVar00275446EvidencePaper_evidenceWBPaper00003496
NamePublic_nameyw23
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00008401
WBStrain00008402
LaboratoryHG
StatusLive
AffectsGeneWBGene00000091
InteractorWBInteraction000519027
WBInteraction000519028
WBInteraction000519029
WBInteraction000519030
WBInteraction000519031
DescriptionPhenotypeWBPhenotype:0000043Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
RemarkMutants have a somewhat increased development time. Hermaphrodites of HG231 age-2(yw23) developed more slowly than N2 hermaphrodites, requiring about 25% more time to begin egg laying at both 20C and 25C.Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
WBPhenotype:0000061Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
RemarkMutants have an increased life span. In a total of 29 trials, the age-2 mutant exhibited a mean increase of ~17% in median longevity. It exhibited a mean increase in maximum longevity of ~21% compared to N2 animals. In a population of 150 HG231 animals studied for survival and mortality rates, mean and median life span was 22% longer than that for N2. HG231 showed a slightly shorter mortality-rate doubling time than N2, but also showed a lower initial (Gompertz) mortality rate. A slightly faster rate of increase of mortality was observed late in its life span, compared to N2.Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
WBPhenotype:0001384Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
RemarkMutants have somewhat reduced fertility. The outcrossed strain, HG231 age-2(yw23), showed much higher fertility at 25C than did non-outcrossed HG23, but less than half that of N2. Fertility of HG231 at 20C was closer to that of N2.Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
WBPhenotype:0001481Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
RemarkMutants have no reduction in swimming rate. The swimming rate of HG231 age-2(yw23) was slightly (5%) greater than that of N2.Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000012Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
RemarkMutants were not dauer constitutive at 27C.Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
WBPhenotype:0000643Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
RemarkMutants appeared normal.Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
WBPhenotype:0000648Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
RemarkMutants appeared normal.Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
WBPhenotype:0000659Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
RemarkMutants appeared normal, including pharyngeal pumping.Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
WBPhenotype:0004001Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
RemarkMutants appeared normal.Paper_evidenceWBPaper00003496
Curator_confirmedWBPerson712
ReferenceWBPaper00003496
MethodAllele