WormBase Tree Display for Variation: WBVar00296774

WBVar00296774 Evidence: Paper_evidence: WBPaper00036484
  Name: Public_name: ky591
  Sequence_details: Mapping_target: T19B4
    SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: CX
    Status: Live
  Affects: Gene: WBGene00006776
  Description: Phenotype: WBPhenotype:0000384 Paper_evidence: WBPaper00036484
        Curator_confirmed: WBPerson712
        Remark: The primary axon of ADL grows into the nerve ring ventrally rather than laterally. This phenotype occurs at a lower frequency than the axon branching phenotype. AVM axons fail to grow ventrally. HSN motor neurons fail to polarize properly. Paper_evidence: WBPaper00036484
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00036484
              Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005661 PATO:0000460 Paper_evidence: WBPaper00036484
                Curator_confirmed: WBPerson712
            WBbt:0003832 PATO:0000460 Paper_evidence: WBPaper00036484
                Curator_confirmed: WBPerson712
      WBPhenotype:0000633 Paper_evidence: WBPaper00036484
        Curator_confirmed: WBPerson712
        Remark: ADL projects a normal dorsal branch but no ventral branch. This phenotype is also observed in L1 animals. Ventrally extended branches of PLM were either missing or shorter than normal. AVM branching was also defective with about half of the animals showing severely shortened or no branches. Paper_evidence: WBPaper00036484
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00036484
              Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005661 PATO:0000460 Paper_evidence: WBPaper00036484
                Curator_confirmed: WBPerson712
            WBbt:0005490 PATO:0000460 Paper_evidence: WBPaper00036484
                Curator_confirmed: WBPerson712
            WBbt:0003832 PATO:0000460 Paper_evidence: WBPaper00036484
                Curator_confirmed: WBPerson712
      WBPhenotype:0000679 Paper_evidence: WBPaper00036484
        Curator_confirmed: WBPerson712
        Remark: MIG-10::GFP was significantly mislocalized and dispersed around the periphery in HSN. Paper_evidence: WBPaper00036484
            Curator_confirmed: WBPerson712
        Variation_effect: Loss_of_function_undetermined_extent: Paper_evidence: WBPaper00036484
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005661 PATO:0000460 Paper_evidence: WBPaper00036484
                Curator_confirmed: WBPerson712
      WBPhenotype:0002491 Paper_evidence: WBPaper00036484
        Curator_confirmed: WBPerson712
        Remark: HSN neurons extend neurites in all directions. Paper_evidence: WBPaper00036484
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00036484
              Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Paper_evidence: WBPaper00036484
                Curator_confirmed: WBPerson712
  Reference: WBPaper00036484
  Method: Allele