WormBase Tree Display for Variation: WBVar02125774
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WBVar02125774 | Evidence | Paper_evidence | WBPaper00041219 | ||||||
---|---|---|---|---|---|---|---|---|---|
Name | Public_name | vt21 | |||||||
Other_name | T23G5.5.1:c.1379G>A | ||||||||
CE25124:p.Gly460Asp | |||||||||
HGVSg | CHROMOSOME_III:g.9245369G>A | ||||||||
Sequence_details | SMap | S_parent | Sequence | T23G5 | |||||
Flanking_sequences | aaaactatcttcatcaaaaatttttgaagg | tggaattctaatcatggaatggctcatcat | |||||||
Mapping_target | T23G5 | ||||||||
Type_of_mutation | Substitution | g | a | Paper_evidence | WBPaper00041219 | ||||
SeqStatus | Sequenced | ||||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Laboratory | BY | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00000934 | |||||||
Transcript | T23G5.5.1 (12) | ||||||||
Interactor | WBInteraction000521891 | ||||||||
Genetics | Interpolated_map_position | III | 0.362032 | ||||||
Description | Phenotype | WBPhenotype:0000273 | Paper_evidence | WBPaper00041219 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Mutants recovered in the screen demonstrated significantly reduced maximal thrashing frequencies in water. | Paper_evidence | WBPaper00041219 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000536 | Paper_evidence | WBPaper00041219 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Our assay of [3H]DA transport activity in COS-7 cells revealed that the mutants significantly reduced DA uptake relative to that displayed by WT HA:DAT-1. dat-1(vt21) exhibited low, but detectible, DA transport activity. | Paper_evidence | WBPaper00041219 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0002114 | Paper_evidence | WBPaper00041219 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | This mutant demonstrates a stable Swip phenotype and can be rescued by reserpine pretreatment. Phenotype not lost after 3X outcrossing. | Paper_evidence | WBPaper00041219 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Rescued_by_transgene | WBTransgene00015309 | ||||||||
Affected_by | Molecule | WBMol:00002955 | Paper_evidence | WBPaper00041219 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0002375 | Paper_evidence | WBPaper00041219 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | dat-1 lines feature a significant number of animals that revert back to relatively normal swimming behavior that we tabulated as reversion incidence (no. revertants/no. paralyzers) and reversion probability (time in reversion/time after paralysis). | Paper_evidence | WBPaper00041219 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_not_observed | WBPhenotype:0000905 | Paper_evidence | WBPaper00041219 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | CEP, ADE and PDE cell bodies and processes appear unaltered relative to N2 animals. | Paper_evidence | WBPaper00041219 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005244 | PATO:0000460 | Paper_evidence | WBPaper00041219 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0005415 | PATO:0000460 | Paper_evidence | WBPaper00041219 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0006747 | PATO:0000460 | Paper_evidence | WBPaper00041219 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0005278 | PATO:0000460 | Paper_evidence | WBPaper00041219 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0002114 | Paper_evidence | WBPaper00041219 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Reference | WBPaper00041219 | ||||||||
Method | Substitution_allele |