WormBase Tree Display for Variation: WBVar02148914
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| WBVar02148914 | Evidence | Paper_evidence | WBPaper00049050 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Public_name | nj73 | |||||||
| Sequence_details | SeqStatus | Pending_curation | |||||||
| Variation_type | Allele | ||||||||
| Origin | Species | Caenorhabditis elegans | |||||||
| Laboratory | IK | ||||||||
| Status | Live | ||||||||
| Affects | Gene | WBGene00006349 | |||||||
| Interactor | WBInteraction000556846 | ||||||||
| WBInteraction000556848 | |||||||||
| WBInteraction000556852 | |||||||||
| WBInteraction000556858 | |||||||||
| WBInteraction000556861 | |||||||||
| Description | Phenotype | WBPhenotype:0000146 | Paper_evidence | WBPaper00049050 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | "To assess the involvement of the Raf pathway in temperature memory variability in AFD, we analyzed temperature-evoked calcium dynamics of AFD in the Raf pathway mutants: lin-45, mek-2, mpk-1, and sur-2. Surprisingly, mutations in Raf pathway genes reduced the variability of response temperatures of AFD. The wild-type response temperatures distributed within a temperature range of about 19.0 degrees Celsius to 22.0 degrees Celsius. By contrast, the response temperatures of the Raf pathway mutants were within a temperature range of about 20.5 degrees Celsius to 21.5 degrees Celsius (Figures 3B and 3C)." | Paper_evidence | WBPaper00049050 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0005662 | PATO:0000460 | Paper_evidence | WBPaper00049050 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Phenotype_assay | Genotype | njIs24[gcy-8p::GCaMP3, gcy-8p::TagRFP] (I); Parent strain: IK1355 | Paper_evidence | WBPaper00049050 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0001236 | Paper_evidence | WBPaper00049050 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | "In the suppressor screen, we utilized pleiotropic defects of cmk-1 mutants: cmk-1 mutants showed abnormally low expression of nhr-38 promoter-fused GFP, an AFD neuron-specific GFP marker (Satterlee et al., 2004). Therefore, we mutagenized cmk-1 mutants carrying nhr-38 promoter-fused GFP and found that a mutation in sur-2 gene that encodes the ortholog of human MED23, a subunit of transcription mediator complex (Singh and Han, 1995), restored the expression of the GFP marker in a cmk-1 mutant background (Figures S3A and S3B)." | Paper_evidence | WBPaper00049050 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0005662 | PATO:0000460 | Paper_evidence | WBPaper00049050 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Phenotype_assay | Genotype | njIs2[nhr-38p::GFP, AIYp::GFP] (V); Parent strain: IK0788 | Paper_evidence | WBPaper00049050 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Reference | WBPaper00049050 | ||||||||
| Remark | Created in the nameserver by Chris Grove | ||||||||
| WBPaper00049050, allele of sur-2, see Table S2 | |||||||||
| Attached WBGene00006349 through auto mapping of cgc_name sur-2. | |||||||||
| Method | Allele |
