WormBase Tree Display for Variation: WBVar02149837

WBVar02149837 Evidence: Paper_evidence: WBPaper00056625
    Person_evidence: WBPerson22699
  Name: Public_name: me101
    Other_name: Y43C5A.6c.1:c.236G>A
      CE25285:p.Arg74His
      CE48196:p.Arg79His
      Y43C5A.6b.1:c.221G>A
      Y43C5A.6a.1:c.335G>A
      CE29064:p.Arg112His
    HGVSg: CHROMOSOME_IV:g.10283785C>T
  Sequence_details: SMap: S_parent: Sequence: Y43C5A
    Flanking_sequences: tcactaattcctttgacatttcggagttcg gtcttgtagtaaatgccagcgattcgtatg
    Mapping_target: Y43C5A
    Type_of_mutation: Substitution: c t
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00048041
    Laboratory: AV
    Person: WBPerson22699
    Status: Live
  Affects: Gene: WBGene00004297
    Transcript: Y43C5A.6c.1 (12)
      Y43C5A.6a.1 (12)
      Y43C5A.6b.1 (12)
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: IV 4.5675
  Description: Phenotype: WBPhenotype:0000050 Paper_evidence: WBPaper00056625
        Curator_confirmed: WBPerson712
        Remark: 100% of eggs laid by me101 mutant hermaphrodites are inviable. Paper_evidence: WBPaper00056625
            Curator_confirmed: WBPerson712
        Image: WBPicture0000014793 Paper_evidence: WBPaper00056625
            Curator_confirmed: WBPerson712
      WBPhenotype:0001372 Paper_evidence: WBPaper00056625
        Curator_confirmed: WBPerson712
        Remark: no RAD-51 foci were observed in the gonads of me101 mutants (Fig 1C) Paper_evidence: WBPaper00056625
            Curator_confirmed: WBPerson712
        Image: WBPicture0000014793 Paper_evidence: WBPaper00056625
            Curator_confirmed: WBPerson712
      WBPhenotype:0001824 Paper_evidence: WBPaper00056625
        Curator_confirmed: WBPerson712
        Remark: late pachytene me101 mutant meiocytes failed to form the six GFP::COSA-1 foci observed in wild-type late pachytene meiocytes Paper_evidence: WBPaper00056625
            Curator_confirmed: WBPerson712
        Image: WBPicture0000014793 Paper_evidence: WBPaper00056625
            Curator_confirmed: WBPerson712
      WBPhenotype:0002012 Paper_evidence: WBPaper00056625
        Curator_confirmed: WBPerson712
        Remark: We also observed structural defects ranging from chromosome fragmentation to the formation of chromosome aggregates in me101 diakinesis-stage oocytes Paper_evidence: WBPaper00056625
            Curator_confirmed: WBPerson712
        Image: WBPicture0000014793 Paper_evidence: WBPaper00056625
            Curator_confirmed: WBPerson712
  Reference: WBPaper00056625
  Remark: Created in the nameserver by Karen Yook
    WBPaper00056625 rad-51
    alt_det = c to t mut_det = R(112)H
  Method: Substitution_allele