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WormBase Tree Display for Variation: WBVar02153265

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Name Class

WBVar02153265NamePublic_nameamt1
Other_nameCE54335:p.Val2GlnfsTer8
D2092.1a.1:c.4_223del
D2092.1b.1:c.361-183_481del
D2092.1c.1:c.241-183_361del
HGVSgCHROMOSOME_I:g.6633185_6633488del
Sequence_detailsSMapS_parentSequenceZC581
Flanking_sequencesttcattttcaaaacggttgacgcaaatatgcaggttttcttttttacttttattaataat
Mapping_targetD2092
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeEngineered_allele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00048141Paper_evidenceWBPaper00059962
WBStrain00048142Paper_evidenceWBPaper00059962
WBStrain00048144Paper_evidenceWBPaper00059962
LaboratoryAMT
Production_methodCRISPR_Cas9
StatusLive
AffectsGeneWBGene00017063
TranscriptD2092.1a.1 (11)
D2092.1c.1VEP_consequencesplice_acceptor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScD2092.1c.1:c.241-183_361del
cDNA_position?-363
CDS_position?-361
Protein_position?-121
Intron_number4/15
Exon_number5/16
D2092.1b.1VEP_consequencesplice_acceptor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScD2092.1b.1:c.361-183_481del
cDNA_position?-481
CDS_position?-481
Protein_position?-161
Intron_number3/14
Exon_number4/15
Possibly_affectsWBGene00017063Paper_evidenceWBPaper00059962
RemarkCGC_name mctp-1
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
RemarkLess eggs laid.Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
WBPhenotype:0000017Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
RemarkAnimals become paralyzed at a lower rate than the wild type animals.Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
Phenotype_assayTreatmentAnimals exposed to 1mM aldicarb.Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
WBPhenotype:0000273Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
WBPhenotype:0001073Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
RemarkIn the absence of food, mctp-1 (amt1) mutant animals laid a reduced number of eggs per hour than wild type hermaphrodites did.Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
WBPhenotype:0002326Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
Remarkmctp-1(amt1) mutant animals crawl at a significantly slower velocities than wild type animals.Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
Phenotype_not_observedWBPhenotype:0000845Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
Phenotype_assayTreatmentAnimals exposed to 0.4mM levamisole.Paper_evidenceWBPaper00059962
Curator_confirmedWBPerson557
ReferenceWBPaper00059962
Remark[2021-02-02T17:36:42.606Z WBPerson1983] New Variation: WBPaper00059962 mctp-1 3.3. mctp-1(amt1) is a loss of function CRISPR alleleTo gain some insight on MCTP-1 function, we generated the mctp-1(amt1) mutant by CRISPR/Cas9. We inserted the CRISPR cassette to delete a 304 base pair region between the first codon of exon five and the last codon of exon six of the mctp-1 locus (Figs. 1A and S1A-A).Curator_confirmedWBPerson1983
[2021-02-02T17:36:42.606Z WBPerson1983] New Variation: WBPaper00059962 mctp-1 3.3. mctp-1(amt1) is a loss of function CRISPR alleleTo gain some insight on MCTP-1 function, we generated themctp-1(amt1)mutant by CRISPR/Cas9. We inserted the CRISPR cassette todelete a 304 base pair region between thefirst codon of exonfive andthe last codon of exon six of themctp-1locus (Figs. 1A and S1A-A).Curator_confirmedWBPerson1983
MethodEngineered_allele