WormBase Tree Display for Expr_pattern: Expr11655
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| Expr11655 | Expression_of | Gene | WBGene00006794 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00006794 | |||
| Expression_data | Anatomy_term | WBbt:0004522 | Certain | |
| WBbt:0006760 | Certain | |||
| GO_term | GO:0005604 | |||
| GO:0071437 | ||||
| GO:0071438 | ||||
| Subcellular_localization | GFP::UNC-60A localized in punctate structures at the AC-basement membrane interface before invasion. To determine whether these structures were invadopodia, their localization was examined relative to F-actin and basement membrane breaching. A tight correlation between F-actin localization and UNC-60A enrichment at the AC-basement membrane interface was observed, as well as localization to the invadopodium that breached the basement membrane. Further, UNC-60A localization to the AC-basement membrane interface was dependent on the integrin INA-1/PAT-3, whose activity is required for invasion and promotes the localization of other invadopodia constituents. Thus, UNC-60A is a component of AC invadopodia. | |||
| Type | Reporter_gene | |||
| Pattern | At the time of invasion GFP::UNC-60A was present throughout the uterine tissue and at elevated levels in the anchor cell (1.35-fold greater levels versus neighboring uterine cells; n = 11 animals examined). GFP::UNC-60A was also more enriched at the invasive cell membrane (1.29-fold enrichment vs. 0.75-fold for neighboring uterine cells; n = 11 animals examined). | |||
| Picture | WBPicture0000013663 | |||
| Reference | WBPaper00045029 | |||
| Transgene | WBTransgene00019822 | |||
| WBTransgene00019823 | ||||
| WBTransgene00019824 |
