WormBase Tree Display for Expr_pattern: Expr15539
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| Expr15539 | Expression_of | Gene | WBGene00020490 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00020490 | |||
| Expression_data | Anatomy_term | WBbt:0003955 | Certain | |
| Type | Reporter_gene | |||
| Pattern | tmc-1 is expressed in the high-threshold mechanosensor, ALA. Previous research has identified C. elegans tmc-1 gene to be expressed in different tissues such as the body wall muscles and neuronal tissue including sensory neurons, cholinergic ventral cord neurons, and pharyngeal neurons (Chatzigeorgiou et al., 2013; Kratsios et al., 2011; Tang et al., 2020; Zhang et al., 2015). To further investigate the role of TMC-1 in mechanosensory neurons, we firstly generated a new transcriptional reporter line for the endogenous C. elegans tmc-1 promoter (4kb upstream of the start of the tmc-1 gene) driving the red fluorescent protein mKate2 (ljEx1221 [Ptmc-1(4kb)::mKate2]). We confirmed previous results that tmc-1 is expressed in ALA (Zhang et al., 2015) using a reporter strain carrying an ALA neuron marker (ljEx463 [Pida-1::GFP]). | |||
| Picture | WBPicture0000015057 | |||
| Reference | WBPaper00061756 | |||
| Transgene | WBTransgene00032451 |
