WormBase Tree Display for Gene: HGNC:8569

HGNC:8569 Identity: Name: CGC_name: Pcsk6 Inferred_automatically: AGR_import
      Other_name: RGD:1604066
        PACE4
        SPC4
        paired basic amino acid cleaving enzyme 4
        paired basic amino acid cleaving system 4
        subtilisin-like proprotein convertase 4
        subtilisin-like protease
        subtilisin/kexin-like protease PACE4
      Public_name: Pcsk6
    DB_info: Database: HGNC id 8569
        AGR cURI HGNC:8569
        EnsEMBL ENSEMBL_geneID ENSG00000140479
        UniProt UniProt_AC P29122
    Species: Homo sapiens
    Status: Live
  Gene_info: Biotype: SO:0001217
    Ortholog: WBGene00002232 Caenorhabditis elegans From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
    Structured_description: Automated_description: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014] Inferred_automatically: AGR_import