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WormBase Tree Display for Gene: WBGene00000018

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Name Class

WBGene00000018SMapS_parentSequenceM79
IdentityVersion1
NameCGC_nameabl-1
Sequence_nameM79.1
Molecular_name (24)
Other_nameCELE_M79.1Accession_evidenceNDBBX284606
Public_nameabl-1
DB_infoDatabase (15)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:19WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classabl
Allele (312)
Legacy_information[C.elegansII] NMK. Major transcript 4.4 kb; sequence (~400 aa) has 62% identity with oncogene v-abl in predicted kinase domain. [Goddard et al. 1986]
StrainWBStrain00002968
WBStrain00040670
WBStrain00040671
WBStrain00040673
RNASeq_FPKM (74)
GO_annotation (65)
OrthologWBGene00058433Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00027163Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00143134Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00124120Caenorhabditis japonicaFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00113564Pristionchus pacificusFrom_analysisInparanoid_8
WormBase-Compara
CBOVI.g11743Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g9246Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g3119Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g5498Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g15985Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g25013Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g2063Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g14551Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g19412Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g20316Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00091.g4060Caenorhabditis angariaFrom_analysisWormBase-Compara
Cnig_chr_X.g23457Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g13783Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00039.g2136Caenorhabditis sinicaFrom_analysisWormBase-Compara
GCK72_008821Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g11351Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g5220Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_X0074300Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrX_pilon.g19928Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00246243Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00263701Strongyloides rattiFrom_analysisWormBase-Compara
FB:FBgn0000017Drosophila melanogasterFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-020809-2Danio rerioFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-100812-9Danio rerioFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:76Homo sapiensFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:77Homo sapiensFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:87859Mus musculusFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:87860Mus musculusFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1590898Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1584969Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
Paralog (45)
Structured_descriptionConcise_descriptionabl-1 encodes, by alternative splicing, three isoforms of a Src homology(SH) 2 and 3 domain-containing non-receptor tyrosine kinase orthologousto human ABL1 (OMIM:189980, mutated in chronic myeloid leukemia) andABL2 (OMIM:164690); ABL-1 inhibits germline apoptosis induced byradiation or by natural aging, but it has no effect on apoptosis inducedby starvation or by chemical mutagens (ethylnitrosourea,ethylmethanesulfonate, cisplatin, etoposide), or on constitutive('physiological') germline apoptosis; at the same time, ABL-1 isrequired for germline apoptosis induced by oxidative, osmotic orheat-shock stress, and is also required for pathogenesis by Shigellaflexneri infecting the intestine; ABL-1-inhibited apoptosis is confinedto a single gonad arm undergoing radiation, having no nonautonomouseffect on the unirradiated arm; abl-1 is expressed in the germline, inmost or all cells of early embryos, and in postembryonic pharynx, tailganglia and ventral nerve cord; abl-1(ok171) mutants are hypersensitiveto germline apoptosis and resistant to S. flexneri infection; bothabl-1(ok171) phenotypes are phenocopied by c-ABL inhibitors such asSTI-571 (Gleevec); ABL-1-inhibited apoptosis requires active CED-3 andEGL-1, inactive CED-9, and active AKT-1, CEP-1, CLK-1, HUS-1, and MRT-2;abl-1(ok171) has no effect on somatic apoptosis, and abl-1(ok171)mutants are generally normal; abl-1 transcripts are enriched in culturedunc-4::GFP neurons.Paper_evidenceWBPaper00024301
WBPaper00025141
WBPaper00027170
WBPaper00027648
WBPaper00027729
WBPaper00029085
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated16 Apr 2007 00:00:00
Automated_descriptionPredicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including defense response to other organism; negative regulation of DNA damage response, signal transduction by p53 class mediator; and negative regulation of engulfment of apoptotic cell. Predicted to be located in cytoplasm. Expressed in Q cell; germ cell; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Is an ortholog of human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) and ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050866Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:76)
DOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:76)
DOID:8552Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:76)
DOID:3908Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:76)
DOID:14330Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:76)
DOID:10534Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:76)
DOID:0080630Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:76)
DOID:4914Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:76)
DOID:9119Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:76)
Molecular_infoCorresponding_CDSM79.1a
M79.1b
M79.1c
M79.1d
M79.1e
M79.1f
M79.1g
M79.1h
Corresponding_CDS_historyM79.1a:wp83
M79.1b:wp83
M79.1c:wp83
Corresponding_transcriptM79.1a.1
M79.1b.1
M79.1c.1
M79.1d.1
M79.1e.1
M79.1f.1
M79.1g.1
M79.1h.1
Other_sequence (21)
Associated_feature (22)
Experimental_infoRNAi_result (16)
Expr_patternChronogram1126
Expr3045
Expr4844
Expr13648
Expr1013054
Expr1030006
Expr1154769
Expr2009093
Expr2027329
Drives_constructWBCnstr00000775
WBCnstr00003474
WBCnstr00011096
WBCnstr00012272
WBCnstr00037793
Construct_productWBCnstr00000775
WBCnstr00037793
Microarray_results (32)
Expression_cluster (112)
Interaction (130)
WBProcessWBbiopr:00000014
WBbiopr:00000066
WBbiopr:00000104
Map_infoMapXPosition2.34106Error0.006695
PositivePositive_cloneM79Inferred_automaticallyFrom sequence, transcript, pseudogene data
MC#191
Mapping_dataMulti_point4134
4652
Pseudo_map_position
ReferenceWBPaper00002948
WBPaper00003205
WBPaper00003827
WBPaper00003935
WBPaper00010154
WBPaper00014039
WBPaper00015440
WBPaper00017950
WBPaper00019320
WBPaper00023979
WBPaper00024301
WBPaper00025141
WBPaper00025649
WBPaper00027170
WBPaper00027223
WBPaper00027258
WBPaper00027648
WBPaper00027700
WBPaper00027729
WBPaper00029085
WBPaper00030417
WBPaper00030839
WBPaper00030934
WBPaper00031082
WBPaper00031095
WBPaper00031923
WBPaper00032243
WBPaper00033098
WBPaper00033164
WBPaper00033433
WBPaper00034773
WBPaper00036252
WBPaper00038223
WBPaper00038491
WBPaper00039177
WBPaper00039521
WBPaper00040714
WBPaper00044067
WBPaper00050367
WBPaper00051021
WBPaper00051452
WBPaper00053171
WBPaper00054918
WBPaper00055090
WBPaper00057026
WBPaper00058442
WBPaper00060859
WBPaper00061670
MethodGene