WormBase Tree Display for Gene: WBGene00000063

WBGene00000063 SMap: S_parent: Sequence: T04C12
  Identity: Version: 1
    Name: CGC_name: act-1 Person_evidence: WBPerson259
      Sequence_name: T04C12.6
      Molecular_name: T04C12.6
        T04C12.6.1
        CE13148
      Other_name: CELE_T04C12.6 Accession_evidence: NDB BX284605
      Public_name: act-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: act
    Allele (13)
    Strain: WBStrain00033488
    In_cluster: act-123
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog: WBGene00025260 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00025261 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00025265 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00025266 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037707 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00041507 Caenorhabditis briggsae From_analysis: OrthoMCL
            Inparanoid_8
      WBGene00041508 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00042553 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00066197 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00132986 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00195125 Caenorhabditis brenneri From_analysis: Inparanoid_8
      WBGene00183122 Caenorhabditis japonica From_analysis: Inparanoid_8
      WBGene00098673 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00225347 Brugia malayi From_analysis: WormBase-Compara
      WBGene00228785 Brugia malayi From_analysis: WormBase-Compara
      WBGene00229498 Brugia malayi From_analysis: WormBase-Compara
      WBGene00229499 Brugia malayi From_analysis: WormBase-Compara
      CSP21.g3544 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP31.g1121 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP38.g15217 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      GCK72_016607 Caenorhabditis remanei From_analysis: WormBase-Compara
      chrV_pilon.g15681 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00239553 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00239554 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00272225 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00276137 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00258064 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00261913 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00264369 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00288575 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000001855 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0000042 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0000043 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      FB:FBgn0000044 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      FB:FBgn0000045 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      FB:FBgn0000047 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      FB:FBgn0000046 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-000329-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-000329-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:132 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:144 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:87904 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:87906 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:628837 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1304556 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:2320108 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
    Paralog (11)
    Structured_description: Concise_description: act-1 encodes an actin isoform that is required for proper body wall muscle and pharyngeal muscle structures and the motility of animals; actins have highly similar amino acid sequences; ACT-1 is identical to ACT-3; act-1 functions redundantly with two other actin isoforms, act-2 and act-3, to control cytoplasmic microfilament function in the early embryo. Paper_evidence: WBPaper00001178
            WBPaper00014413
            WBPaper00027028
          Curator_confirmed: WBPerson324
          Date_last_updated: 29 Mar 2007 00:00:00
      Automated_description: Predicted to be a structural constituent of cytoskeleton. Involved in cortical actin cytoskeleton organization; embryo development; and mitotic cytokinesis. Located in striated muscle thin filament. Expressed in body wall musculature and gonad. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Is an ortholog of human ACTB (actin beta). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1588 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:132)
      DOID:0081113 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:144)
      DOID:10881 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:132)
      DOID:0081112 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:132)
      DOID:0110550 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:144)
  Molecular_info: Corresponding_CDS: T04C12.6
    Corresponding_transcript: T04C12.6.1
    Other_sequence (456)
    Associated_feature: WBsf647226
      WBsf647227
      WBsf661678
      WBsf661679
      WBsf1001264
      WBsf1001265
      WBsf1020400
      WBsf232452
      WBsf232453
      WBsf232454
  Experimental_info: RNAi_result (55)
    Expr_pattern: Expr558
      Expr2793
      Expr4555
      Expr9252
      Expr1030024
      Expr1156000
      Expr2009221
      Expr2027458
    Drives_construct: WBCnstr00006031
      WBCnstr00006032
      WBCnstr00013852
      WBCnstr00037760
    Construct_product: WBCnstr00015675
      WBCnstr00015678
      WBCnstr00037760
      WBCnstr00038658
    Antibody: WBAntibody00001783
    Microarray_results: SMD_T04C12.6
      GPL19516_CGZ0033111
      GPL19516_CGZ0033112
      GPL19516_CGZ0033113
      GPL19516_CGZ0033114
      GPL21109_T04C12.6.1
      GPL8304_CE_WBGene00000063_B
      GPL9450_T04C12.6
      cea2.c.38095
    Expression_cluster (171)
    Interaction (326)
    WBProcess: WBbiopr:00000096
  Map_info: Map: V Position: 2.94475 Error: 0.000513
    Positive: Positive_clone: T04C12 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (106)
  Remark: T04C12.4 changed to T04C12.6. email from JAH 0109
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene