WormBase Tree Display for Gene: WBGene00000064

WBGene00000064 SMap: S_parent: Sequence: T04C12
  Identity: Version: 1
    Name: CGC_name: act-2 Person_evidence: WBPerson259
      Sequence_name: T04C12.5
      Molecular_name: T04C12.5
        T04C12.5.1
        CE13150
      Other_name: act2 Accession_evidence: EMBL X16797
        CELE_T04C12.5 Accession_evidence: NDB BX284605
      Public_name: act-2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: act
    Allele (25)
    Strain: WBStrain00031881
      WBStrain00005465
      WBStrain00007342
      WBStrain00007350
      WBStrain00007351
      WBStrain00007357
      WBStrain00007359
    In_cluster: act-123
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog: WBGene00025260 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00025261 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00025265 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00025266 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037707 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00041507 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
      WBGene00041508 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00042553 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00153714 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
      WBGene00085263 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00051763 Caenorhabditis remanei From_analysis: OMA
      WBGene00066199 Caenorhabditis remanei From_analysis: OMA
      WBGene00066197 Caenorhabditis remanei From_analysis: OMA
      WBGene00098673 Pristionchus pacificus From_analysis: OMA
            WormBase-Compara
      WBGene00195128 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00225347 Brugia malayi From_analysis: WormBase-Compara
      WBGene00228785 Brugia malayi From_analysis: WormBase-Compara
      WBGene00229498 Brugia malayi From_analysis: WormBase-Compara
      WBGene00229499 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g1061 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g3543 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g13349 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g4680 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g18226 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g1120 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g9612 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g18789 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP40.g15794 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cnig_chr_V.g19284 Caenorhabditis nigoni From_analysis: WormBase-Compara
      FL83_23989 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_016605 Caenorhabditis remanei From_analysis: WormBase-Compara
      Sp34_50311800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g15680 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00239553 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00239554 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00272225 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00276137 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00258064 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00261913 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00264369 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00288575 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000001855 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0000042 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0000043 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      FB:FBgn0000044 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      FB:FBgn0000045 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      FB:FBgn0000047 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      FB:FBgn0000046 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-000329-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-000329-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:132 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:144 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:87904 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:87906 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:628837 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1304556 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:2320108 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
    Paralog (11)
    Structured_description: Concise_description: act-2 encodes one of five C. elegans actins; act-2 functions redundantly in early embryonic cortical microfilaments with act-1 and act-3, and dominant mutations in act-2 result in uncoordinated locomotion; an ACT-2::GFP reporter fusion is expressed in the cytoplasm of embryonic cells and is also found in contractile filaments in adult muscle cells. Paper_evidence: WBPaper00001178
            WBPaper00001709
            WBPaper00027028
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 29 May 2013 00:00:00
      Automated_description: Predicted to enable ATP binding activity. Involved in several processes, including cortical actin cytoskeleton organization; cytoskeleton-dependent cytokinesis; and embryo development. Located in actin filament and cell cortex. Expressed in body wall musculature; gonad; hypodermis; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Is an ortholog of human ACTB (actin beta). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1588 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:132)
      DOID:0081113 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:144)
      DOID:10881 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:132)
      DOID:0081112 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:132)
      DOID:0110550 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:144)
  Molecular_info: Corresponding_CDS: T04C12.5
    Corresponding_transcript: T04C12.5.1
    Other_sequence (476)
    Associated_feature (16)
  Experimental_info: RNAi_result (49)
    Expr_pattern: Expr3813
      Expr4555
      Expr1030025
      Expr1155999
      Expr2009222
      Expr2027459
    Drives_construct: WBCnstr00011672
      WBCnstr00016094
      WBCnstr00037759
    Construct_product: WBCnstr00011672
      WBCnstr00016094
      WBCnstr00037759
    Antibody: WBAntibody00001783
    Microarray_results (23)
    Expression_cluster (206)
    Interaction (415)
    WBProcess: WBbiopr:00000096
  Map_info: Map: V Position: 2.94351 Error: 0.003498
    Positive: Positive_clone: T04C12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 6177
        6203
      Multi_point: 4140
        4141
  Reference (62)
  Remark: M03F4.2 connection removed since latter is on another chromosome. [sdm 0107]
    Sequences T04C12.4 & T04C12.6 removed. email from JAH 0109
  Method: Gene