| WBGene00000065 | SMap | S_parent | Sequence | T04C12 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | act-3 | Person_evidence | WBPerson259 |
| | | Sequence_name | T04C12.4 |
| | | Molecular_name | T04C12.4 |
| | | | T04C12.4.1 |
| | | | CE13148 |
| | | | T04C12.4.2 |
| | | | T04C12.4.3 |
| | | Other_name | act1 | Accession_evidence | EMBL | X16796 |
| | | | act3 | Accession_evidence | EMBL | X16798 |
| | | | CELE_T04C12.4 | Accession_evidence | NDB | BX284605 |
| | | Public_name | act-3 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | act |
| | Allele (40) |
| | Strain | WBStrain00033516 |
| | | WBStrain00005465 |
| | In_cluster | act-123 |
| | RNASeq_FPKM (74) |
| | Ortholog (46) |
| | Paralog (11) |
| | Structured_description | Concise_description | act-3 encodes an invertebrate actin, highly similar to ACT-1, ACT-2, and ACT-4, that functions in body wall muscle; act-3 functions with two other action isoforms, act-1 and act-2, to control cytoplasmic microfilament function in the early embryo. | Paper_evidence | WBPaper00000741 |
| | | | | | WBPaper00001178 |
| | | | | | WBPaper00001709 |
| | | | | | WBPaper00014413 |
| | | | | | WBPaper00027028 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 29 Mar 2007 00:00:00 |
| | | Automated_description | Expressed in gonad and head. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Human ACTB Contributes to nucleosomal DNA binding activity. Human ACTB enables several functions, including Tat protein binding activity; enzyme binding activity; and kinesin binding activity. A structural constituent of postsynaptic actin cytoskeleton. Is predicted to encode a protein with the following domains: ATPase, nucleotide binding domain; Phosphorylation site; Actin; and Actin family. Is an ortholog of human ACTB (actin beta). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:1588 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) |
| | | DOID:0081113 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:144) |
| | | DOID:10881 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) |
| | | DOID:0081112 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) |
| | | DOID:0110550 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:144) |
| Molecular_info | Corresponding_CDS | T04C12.4 |
| | Corresponding_transcript | T04C12.4.1 |
| | | T04C12.4.2 |
| | | T04C12.4.3 |
| | Other_sequence (48) |
| | Associated_feature (11) |
| Experimental_info | RNAi_result (47) |
| | Expr_pattern | Chronogram981 |
| | | Expr4555 |
| | | Expr6598 |
| | | Expr14934 |
| | | Expr1030026 |
| | | Expr1155998 |
| | | Expr2009223 |
| | | Expr2027460 |
| | Drives_construct | WBCnstr00002476 |
| | | WBCnstr00037758 |
| | | WBCnstr00041591 |
| | Construct_product | WBCnstr00037758 |
| | Antibody | WBAntibody00001783 |
| | Microarray_results (48) |
| | Expression_cluster | WBPaper00005943:L3_specific |
| | | WBPaper00024704:Soluble_protein |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1310 |
| | | WBPaper00029359_1364 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1578 |
| | | WBPaper00029359_1604 |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00035963:S.aureus_24h_upregulated |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045316:prg-1_upregulated_L1 |
| | | WBPaper00045316:prg-1_upregulated_L2 |
| | | WBPaper00045316:prg-1_upregulated_L3 |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:lin-35(n745)_downregulated |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048971:daf-16(mgDf50)_downregulated_L1 |
| | | WBPaper00048988:daf-2(e1370)_daf-16(mu86)_upregulated_neuron |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053318:Aging_downregulated_mRNA_N2 |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053814:25C_downregulated_OP50 |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055648:male-vas-deferens_expressed |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055969:electromagnetic-field_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060084:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061340:BWM_far_posterior |
| | | WBPaper00061340:mu_int_mu_anal |
| | | WBPaper00061340:mu_sph |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:sec-24.1_3187-F07F6.4 |
| | | WBPaper00061651:Gonadal_sheath_cell_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061651:Spermatheca_enriched |
| | | WBPaper00062002:Day4-adult_secretome |
| | | WBPaper00062002:L3_secretome |
| | | WBPaper00062143:PQN-59_interacting |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:daf-16(RNAi)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064315:mes-4(bn73)_downregulated_EGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064735:bet-1(uth41)_vs_N2_upregulated |
| | | WBPaper00064735:bet-1B(OE)_vs_N2_upregulated |
| | | WBPaper00064933:E.coli-binding_secret_protein |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065623:143 |
| | | WBPaper00065841:38_1 |
| | | cgc4386_cluster_6_6 |
| | | cgc4489_group_24 |
| | | WBPaper00025032:cluster_15 |
| | | WBPaper00025032:cluster_32 |
| | | WBPaper00025032:cluster_55 |
| | | WBPaper00025032:cluster_64 |
| | | WBPaper00025032:cluster_89 |
| | | WBPaper00025032:cluster_124 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035560:ahr-1_downregulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5 |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042128:gei-8(ok1671)_upregulated |
| | | WBPaper00042178:hlh-29(tm284)_upregulated |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00049311:sAg-MNP_regulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(53_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | | [cgc6390]:Cluster_C |
| | Interaction (298) |
| Map_info | Map | V | Position | 2.92811 | Error | 0.004379 |
| | Positive | Positive_clone | T04C12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4140 |
| | | | 4141 |
| | Pseudo_map_position |
| Reference (63) |
| Remark | M03F4.2 connection removed since latter is on another chromosome. [sdm 0107] |
| | T04C12.6 connection removed. email from JAH 0109. |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
