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WormBase Tree Display for Gene: WBGene00000464

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Name Class

WBGene00000464SMapS_parentSequenceY54F10AM
IdentityVersion2
NameCGC_nameceh-44Person_evidenceWBPerson83
Sequence_nameY54F10AM.4
Molecular_nameY54F10AM.4
Y54F10AM.4.1
CE27288
Other_namecone-1Person_evidenceWBPerson260
Laboratory_evidenceOH
Remarkcone-1 is the gene name from transcripts b and c, as these form a gene fuctionally distinct from the a transcript
CELE_Y54F10AM.4Accession_evidenceNDBBX284603
Public_nameceh-44
DB_infoDatabaseAceViewgene3D635
WormQTLgeneWBGene00000464
WormFluxgeneWBGene00000464
NDBlocus_tagCELE_Y54F10AM.4
PanthergeneCAEEL|WormBase=WBGene00000464|UniProtKB=Q9BL02
familyPTHR14043
NCBIgene80510351
RefSeqproteinNM_065175.9
SwissProtUniProtAccQ9BL02
UniProt_GCRPUniProtAccQ9BL02
OMIMgene610648
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
204 Jan 2022 01:23:28WBPerson1983EventSplit_intoWBGene00306126
Split_intoWBGene00306126
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classceh
AlleleWBVar02157370Inferred_automaticallyFrom strain object: OH16376
WBVar00049258
WBVar01951782
WBVar00030236
WBVar01951783
WBVar00049263
WBVar00030241
WBVar00049268
WBVar00030251
WBVar00049273
WBVar00030256
WBVar00810173
WBVar00049278
WBVar00810174
WBVar00030261
WBVar01500082
WBVar00810175
WBVar00810176
WBVar00049283
WBVar01893087
WBVar00810177
WBVar02097795
WBVar00810178
WBVar00030266
WBVar00810179
WBVar01655715
WBVar00049288
WBVar01655716
WBVar00030271
WBVar01999180
WBVar00810180
WBVar01999181
WBVar00810181
WBVar01655717
WBVar00810182
WBVar00049293
WBVar01655718
WBVar01999182
WBVar01655719
WBVar00810183
WBVar00030276
WBVar01999183
WBVar00810184
WBVar02114364
WBVar01999184
WBVar01655720
WBVar01655721
WBVar01999185
WBVar00810185
WBVar00049298
WBVar01655722
WBVar00810186
WBVar00030281
WBVar01655723
WBVar00810187
WBVar00049303
WBVar01655724
WBVar02085293
WBVar00810188
WBVar01655725
WBVar00810189
WBVar01497887
WBVar02085294
WBVar00810190
WBVar01655726
WBVar00049308
WBVar01655727
WBVar00810191
WBVar00810192
WBVar01655728
WBVar01655729
WBVar00810193
WBVar01655730
WBVar01938103
WBVar00810194
WBVar01667201
WBVar00049313
WBVar01655731
WBVar01938105
WBVar00810195
WBVar02086588
WBVar00030301
WBVar01938106
WBVar00810196
WBVar01655732
WBVar00810197
WBVar01938107
WBVar01655733
WBVar00810198
WBVar01938108
WBVar00810199
WBVar01938109
WBVar00810200
WBVar02007613
WBVar01938110
WBVar00810201
WBVar01938112
WBVar00810202
WBVar00810203
WBVar00810204
WBVar02041278
WBVar01328120
WBVar00810205
WBVar01328121
WBVar00810206
WBVar00810207
WBVar01328124
WBVar01771041
WBVar01328129
WBVar00810208
WBVar00810209
WBVar01771042
WBVar01328130
WBVar01771043
WBVar00810210
WBVar02092491
WBVar01328133
WBVar02092492
WBVar01771044
WBVar00810211
WBVar01771045
WBVar00810212
WBVar01498832
WBVar00810213
WBVar01771046
WBVar01771047
WBVar00810214
WBVar00810215
WBVar00810216
WBVar01407924
WBVar01407925
WBVar00810217
WBVar00810218
WBVar01407926
WBVar01912929
WBVar00810219
WBVar01407927
WBVar01912930
WBVar01407928
WBVar00810220
WBVar00249941
WBVar01407929
WBVar00810221
WBVar01912931
WBVar01912932
WBVar00810222
WBVar00810223
WBVar01722204
WBVar00810224
WBVar00810225
WBVar00810226
WBVar00810227
WBVar00810228
WBVar00561698
WBVar00810229
WBVar00561701
WBVar00810230
WBVar00561721
WBVar00810231
WBVar00810232
WBVar00561723
WBVar00810233
WBVar00810234
WBVar00810235
WBVar00810236
WBVar01962221
WBVar00810237
WBVar01962222
WBVar01962223
WBVar00810238
WBVar00307831
WBVar00810239
WBVar01962226
WBVar00392122
WBVar00392123
WBVar01962227
WBVar00810240
WBVar00392124
WBVar00810241
WBVar00392125
WBVar00810242
WBVar00810243
WBVar00392126
WBVar00810244
WBVar01709673
WBVar00392127
WBVar00810245
WBVar00392128
WBVar00810246
WBVar00392129
WBVar00392130
WBVar00810247
WBVar00392131
WBVar00810248
WBVar01944552
WBVar00392132
WBVar00097589
WBVar01944554
WBVar00810249
WBVar00810250
WBVar00097590
WBVar00392133
WBVar00810251
WBVar00392134
WBVar01396188
WBVar00810252
WBVar00392135
WBVar00810253
WBVar01396189
WBVar00392136
WBVar00810254
WBVar00392137
WBVar01606934
WBVar01396191
WBVar00392138
WBVar00810255
WBVar00392139
WBVar01606935
WBVar00097598
WBVar01498875
WBVar01396192
WBVar00810256
WBVar00392140
WBVar01396193
WBVar00097599
WBVar00810257
WBVar00392141
WBVar00810258
WBVar00097600
WBVar00810259
WBVar00392142
WBVar00392143
WBVar00810260
WBVar00392144
WBVar00810261
WBVar00810262
WBVar00392145
WBVar00810263
WBVar00392146
WBVar00810264
WBVar00392147
WBVar00810265
WBVar00392148
WBVar00810266
WBVar00392149
WBVar00392150
WBVar00810267
WBVar00392151
WBVar00810268
WBVar02074074
WBVar00810269
WBVar00810270
WBVar02074075
WBVar01496497
WBVar00810271
WBVar02074076
WBVar00810272
WBVar01259771
WBVar00810273
WBVar01259772
WBVar00810274
WBVar00810275
WBVar01259780
WBVar01259781
WBVar00810276
WBVar00810277
WBVar00810278
WBVar01496504
WBVar01499817
WBVar00810279
WBVar01259796
WBVar01259797
WBVar00810280
WBVar00810281
WBVar01259799
WBVar01259801
WBVar02030565
WBVar01541004
WBVar02018696
WBVar01541005
WBVar02096797
WBVar01541006
WBVar01259808
WBVar01541007
WBVar02096798
WBVar01918552
WBVar01541008
WBVar02011494
WBVar01541009
WBVar01541010
WBVar01541011
WBVar00049153
WBVar01541012
WBVar00049158
WBVar00049163
WBVar00049168
WBVar01415687
WBVar02033986
WBVar01415690
WBVar00049173
WBVar01490458
WBVar00049188
WBVar00049193
WBVar01627807
WBVar01627808
WBVar00030181
WBVar00030186
WBVar00049208
WBVar00030191
WBVar01499491
WBVar01837284
WBVar00049213
WBVar01837285
WBVar00030196
WBVar02131643
WBVar00235944
WBVar01444413
WBVar00235945
WBVar00233369
WBVar01444414
WBVar02151036
WBVar01444415
WBVar01444418
WBVar00235947
WBVar01444421
WBVar00049228
WBVar00030206
WBVar01444422
WBVar01444423
WBVar01444424
WBVar00049233
WBVar01444425
WBVar01444427
WBVar01444429
WBVar00049238
WBVar00030216
WBVar02073208
WBVar01565754
WBVar01565755
WBVar00049243
WBVar01565756
WBVar01565757
WBVar00030226
WBVar01565758
WBVar01565759
WBVar01548711
WBVar00049253
WBVar01785192
WBVar01565760
WBVar01548712
WBVar01951780
WBVar00030231
WBVar01951781
Strain (13)
RNASeq_FPKM (74)
GO_annotation (15)
Contained_in_operonCEOP3078
Ortholog (42)
ParalogWBGene00000444Caenorhabditis elegansFrom_analysisTreeFam
WBGene00000459Caenorhabditis elegansFrom_analysisTreeFam
WBGene00000460Caenorhabditis elegansFrom_analysisTreeFam
WBGene00306126Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionceh-44 encodes at least three proteins via alternative splicing; the CEH-44A protein is an ortholog of the CUX class of CUT homeodomain proteins, expressed in early embryos (mostly anterior in the comma stage), in the larval nerve ring and the adult gonad; the CUX class includes Drosophila CUT, human CUTL1 and human CUTL2; ceh-44 is a complex gene, in which two alternatively spliced protein products completely lack the homeodomain and cut domain, and instead form a different protein, CASP; in vertebrates, this alternative splicing also occurs, while in Drosophila Casp as been lost; CASP proteins are also found in plants and fungi (though not associated with homeodomains); like its orthologs, CEH-44A has three cut domains upstream of the homeodomain; the cut domain is a DNA binding domain.Paper_evidenceWBPaper00005164
WBPaper00005654
Person_evidenceWBPerson83
Curator_confirmedWBPerson13481
WBPerson1843
Date_last_updated26 Jun 2011 00:00:00
Automated_descriptionPredicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in head muscle; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including developmental and epileptic encephalopathy 67; gastrointestinal system cancer (multiple); and insulinoma. Is an ortholog of human CUX2 (cut like homeobox 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:3892Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2557)
DOID:3908Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2557)
DOID:10534Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2557)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2557)
DOID:0112203Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:19347)
Molecular_infoCorresponding_CDSY54F10AM.4
Corresponding_CDS_historyY54F10AM.4b:wp91
Y54F10AM.4b:wp283
Y54F10AM.4c:wp283
Corresponding_transcriptY54F10AM.4.1
Associated_feature (21)
Transcription_factorWBTranscriptionFactor000292
Experimental_infoRNAi_resultWBRNAi00106736Inferred_automaticallyRNAi_primary
WBRNAi00057401Inferred_automaticallyRNAi_primary
WBRNAi00107381Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00002360
WBCnstr00002361
WBCnstr00002788
WBCnstr00012875
Microarray_results (16)
Expression_cluster (141)
SAGE_tag (15)
Interaction (58)
Map_infoMapIIIPosition-12.9684Error0.140862
PositivePositive_cloneY54F10AMInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4306
4846
4812
Pseudo_map_position
Reference (16)
RemarkSequence connection from [Pujol N]. krb 13/11/01
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
ceh-44 had 3 isoforms, a,b and c. Only the a isoform is a homeobox gene (hence ceh-44) - i.e. only the a-isoform specific exons have the CUT and homeodomain thats the key feature of this protein. The b and c isoforms are a functionally TOTALLY different protein - a Golgi associated protein called CASP. This gene structure is conserved in vertebrates (and it is in vertebrates where this protein has been shown to be a Golgi protein). Thomas Burglin has written about this. See Fig.6 in Burglin et al Int. J. Dev. Biol. 46: 115-123 (2002) Loss and gain of domains during evolution of cut superclass homeobox genes. I would like to argue to call the b and c isoforms (Y54F10AM.4b and Y54F10AM.4c) = cone-1. Decided to rename these Isoforms to have a unique WBGene accession and a new sequence name Y54F10AM.16.Person_evidenceWBPerson260
Curator_confirmedWBPerson1983
MethodGene