| WBGene00000901 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | W01G7 |
| Identity | Version | 1 |
| | Name | CGC_name | daf-5 | Person_evidence | WBPerson521 |
| | | Sequence_name | W01G7.1 |
| | | Molecular_name | W01G7.1 |
| | | | W01G7.1.1 |
| | | | CE18985 |
| | | | W01G7.1.2 |
| | | Other_name | CELE_W01G7.1 | Accession_evidence | NDB | BX284602 |
| | | Public_name | daf-5 |
| | DB_info | Database | AceView | gene | 2O324 |
| | | | WormQTL | gene | WBGene00000901 |
| | | | SignaLink | protein | WBGene00000901 |
| | | | WormFlux | gene | WBGene00000901 |
| | | | NDB | locus_tag | CELE_W01G7.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000901|UniProtKB=G5EDM7 |
| | | | | family | PTHR10005 |
| | | | NCBI | gene | 175054 |
| | | | RefSeq | protein | NM_064540.7 |
| | | | SwissProt | UniProtAcc | G5EDM7 |
| | | | UniProt_GCRP | UniProtAcc | G5EDM7 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | daf |
| | Reference_allele | WBVar00143963 |
| | Allele (641) |
| | Legacy_information | e1386 : defective dauer formation (daf-2 suppressible). ES1 ME3. NA11. |
| | | See also e1385, e1386 |
| | | [C.elegansII] e1386 : defective dauer formation. ES1 ME3. OA11: e1385 etc. [Riddle et al. 1991; Thomas et al. 1993; DR] |
| | Strain | WBStrain00026946 |
| | | WBStrain00030737 |
| | | WBStrain00004317 |
| | RNASeq_FPKM (74) |
| | GO_annotation (20) |
| | Ortholog (28) |
| | Structured_description | Concise_description | daf-5 is an ortholog of human SKOR1 (SKI family transcriptional corepressor 1) and SKOR2 (SKI family transcriptional corepressor 2); daf-5 is involved in dauer entry, determination of adult lifespan, lipid storage, negative regulation of transcription from RNA polymerase II promoter, positive regulation of dauer larval development and transforming growth factor beta receptor signaling pathway; daf-5 is predicted to have SMAD binding activity, based on protein domain information; daf-5 is expressed in the muscle cell, gon_herm_dtc_P, gon_herm_dtc_A, certain interneurons, ganglion, hypodermis, intestine, and the head neurons; daf-5 is localized to the cytoplasm and the nucleus. | Paper_evidence (18) |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson1843 |
| | | | | Date_last_updated | 10 Apr 2017 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of dauer larval development; and transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. Expressed in several structures, including XXX cell; ganglia; hermaphrodite distal tip cell; intestine; and muscle cell. Is an ortholog of human SKI (SKI proto-oncogene) and SKIL (SKI like proto-oncogene). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | W01G7.1 |
| | Corresponding_transcript | W01G7.1.1 |
| | | W01G7.1.2 |
| | Other_sequence | LSC01469_1 |
| | | CD203263.1 |
| | | CR09984 |
| | | CRC12262_1 |
| | Associated_feature (24) |
| Experimental_info | RNAi_result (17) |
| | Expr_pattern | Expr2861 |
| | | Expr2880 |
| | | Expr2881 |
| | | Expr1028726 |
| | | Expr1030565 |
| | | Expr1158077 |
| | | Expr2010780 |
| | | Expr2029017 |
| | Drives_construct | WBCnstr00000991 |
| | | WBCnstr00000992 |
| | | WBCnstr00011005 |
| | | WBCnstr00011006 |
| | | WBCnstr00037209 |
| | Construct_product | WBCnstr00011005 |
| | | WBCnstr00037209 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049001:EVN_enriched |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(+) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:clk-1(qm30)_upregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060951:mrpl-2(osa3)_upregulated |
| | | WBPaper00061340:g1A_g1P |
| | | WBPaper00061340:hyp3 |
| | | WBPaper00061340:ILso |
| | | WBPaper00061340:Z1_Z4 |
| | | WBPaper00061405:S.aureus_downregulated_starvation |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:trcs-2_5724-R11A8.7_17645 |
| | | WBPaper00061651:ADA_enriched |
| | | WBPaper00061651:BDU_enriched |
| | | WBPaper00061651:RIH_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | cgc4489_group_20 |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00046548:dafachronic-acid_downregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00053550:daf-19(m86)_upregulated_L1 |
| | Interaction (235) |
| | Anatomy_function | WBbtf0259 |
| | | WBbtf0260 |
| | | WBbtf0261 |
| | WBProcess | WBbiopr:00000025 |
| Map_info | Map | II | Position | 22.361 | Error | 0.042113 |
| | Well_ordered |
| | Positive | Positive_clone | W01G7 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 270 |
| | | | 416 |
| | | | 417 |
| | | Multi_point | 1396 |
| | | | 4984 |
| Reference (116) |
| Remark | Sequence connection from [Edgley ML, Riddle DR] |
| Method | Gene |
