| WBGene00001049 | SMap | S_parent | Sequence | F33H2 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | dog-1 | Person_evidence | WBPerson533 |
| | | Sequence_name | F33H2.1 |
| | | Molecular_name | F33H2.1 |
| | | | F33H2.1.1 |
| | | | CE17764 |
| | | Other_name | CELE_F33H2.1 | Accession_evidence | NDB | BX284601 |
| | | Public_name | dog-1 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | dog |
| | Allele (117) |
| | Strain | WBStrain00001778 |
| | | WBStrain00003477 |
| | | WBStrain00035483 |
| | RNASeq_FPKM (74) |
| | GO_annotation (25) |
| | Contained_in_operon | CEOP1772 |
| | Ortholog (43) |
| | Paralog | WBGene00010839 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00009124 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00044493 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00021752 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | dog-1 encodes a helicase homologous to the human FANCJ/BRIP1/BACH1 helicase; DOG-1 is required for interstrand cross-link (ICL) repair and for maintenance of polyguanine tracts of germline and somatic DNA by resolving the secondary structure that can occur in guanine-rich DNA during lagging-strand DNA synthesis; genetic analysis suggests that dog-1 functions downstream of fcd-2 and rad-51 in mediating ICL and that fcd-2 activity is required for G/C tract maintenance in the absence of dog-1. | Paper_evidence | WBPaper00005308 |
| | | | | | WBPaper00031336 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 25 May 2011 00:00:00 |
| | | Automated_description | Predicted to enable DNA helicase activity. Involved in DNA metabolic process; regulation of DNA-templated DNA replication; and reproduction. Predicted to be located in nucleus. Expressed in head and tail. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Down syndrome; Fanconi anemia complementation group J; and cervical squamous cell carcinoma. Is an ortholog of human BRIP1 (BRCA1 interacting helicase 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:13636 | Homo sapiens | Paper_evidence | WBPaper00031336 |
| | | | | Accession_evidence | OMIM | 227650 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 05 Mar 2018 00:00:00 |
| | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) |
| | | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) |
| | | DOID:14250 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) |
| | | DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) |
| | | DOID:3744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) |
| | | DOID:1588 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) |
| | | DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) |
| | | DOID:0111097 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) |
| | Disease_relevance | Human FANCJ/BRIP1/BACH1 encodes a dead-box helicase and BRCA1-binding protein mutated in Fanconi anemia (FA) and early-onset breast cancer; Fanconi anemia is a disorder characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand cross-links (ICLs); studies in C.elegans indicate that dog-1, the C. elegans functional orthlog of FANCJ, functions to maintain G-rich DNA and reduce ICL-induced damage, together with other FA pathway components. | Homo sapiens | Paper_evidence | WBPaper00041180 |
| | | | | Curator_confirmed | WBPerson324 |
| Models_disease_asserted | WBDOannot00000099 |
| | WBDOannot00000493 |
| | WBDOannot00000494 |
| Molecular_info | Corresponding_CDS | F33H2.1 |
| | Corresponding_transcript | F33H2.1.1 |
| | Other_sequence (23) |
| | Associated_feature | WBsf649787 |
| | | WBsf665194 |
| | | WBsf220678 |
| Experimental_info | RNAi_result (11) |
| | Expr_pattern (9) |
| | Drives_construct | WBCnstr00002591 |
| | | WBCnstr00004379 |
| | | WBCnstr00037121 |
| | Construct_product | WBCnstr00037121 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00029359_1124 |
| | | WBPaper00029359_1141 |
| | | WBPaper00029359_1227 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1304 |
| | | WBPaper00029359_1351 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1497 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1525 |
| | | WBPaper00029359_1604 |
| | | WBPaper00029359_1682 |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032031:DConiospora_upregulated_cDNA_24h |
| | | WBPaper00032425:up_in_lin-35 |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00038168:lin-35_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched |
| | | WBPaper00048690:male-Z1-Z4-daughter_enriched |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:hypodermis_enriched |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_downregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059598:HeatShock_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061274:microgravity_upregulated |
| | | WBPaper00061340:M4_parent |
| | | WBPaper00061340:OLQ_grandparent |
| | | WBPaper00061340:Parents_of_Y_DA6_DA7_DA9 |
| | | WBPaper00061340:Parent_of_exc_gland_AVK |
| | | WBPaper00061340:Parent_of_g1P_I3 |
| | | WBPaper00061340:Parent_of_tail_spike_and_hyp10 |
| | | WBPaper00061340:RIB |
| | | WBPaper00061527:F54E7.8-orc-5_6376 |
| | | WBPaper00062056:efl-1(se1)_upregulated |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062056:lin-36(n766)_upregulated |
| | | WBPaper00062056:lin-36(we31)_upregulated |
| | | WBPaper00062056:lin-36(we36)_upregulated |
| | | WBPaper00062056:lin-37(n758)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062590:Aging_upregulated_neuron |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064107:lin-35(n745)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064735:bet-1B(OE)_vs_N2_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_4 |
| | | WBPaper00025032:cluster_36 |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_6 |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00040426:CYE-1_CDK-2AF_upregulated |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045960:L1-L4-lethargus_downregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(101_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_F |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction | WBInteraction000052805 |
| | | WBInteraction000052900 |
| | | WBInteraction000161806 |
| | | WBInteraction000161819 |
| | | WBInteraction000163067 |
| | | WBInteraction000351166 |
| | | WBInteraction000372486 |
| | | WBInteraction000441914 |
| | | WBInteraction000500003 |
| | | WBInteraction000500004 |
| Map_info | Map | I | Position | 29.4332 | Error | 0.084094 |
| | Positive | Positive_clone | F33H2 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4499 |
| | Pseudo_map_position |
| Reference (50) |
| Remark | Sequence connection from [Cheung I, Schertzer M, Rose A, Lansdorp RM], [020809 krb] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
