WBGene00001064 | SMap | S_parent | Sequence | T14B4 |
| Identity | Version | 1 |
| | Name | CGC_name | dpy-2 | Person_evidence | WBPerson261 |
| | | Sequence_name | T14B4.6 |
| | | Molecular_name | T14B4.6 |
| | | | T14B4.6.1 |
| | | | CE04953 |
| | | Other_name | rol-2 |
| | | | CELE_T14B4.6 | Accession_evidence | NDB | BX284602 |
| | | Public_name | dpy-2 |
| | DB_info | Database | AceView | gene | 2H5 |
| | | | WormQTL | gene | WBGene00001064 |
| | | | WormFlux | gene | WBGene00001064 |
| | | | NDB | locus_tag | CELE_T14B4.6 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001064|UniProtKB=P35799 |
| | | | | family | PTHR24637 |
| | | | NCBI | gene | 174107 |
| | | | RefSeq | protein | NM_062966.9 |
| | | | SwissProt | UniProtAcc | P35799 |
| | | | UniProt_GCRP | UniProtAcc | P35799 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | dpy |
| | Reference_allele | WBVar00142906 |
| | Allele (30) |
| | Legacy_information | e8 : dumpy left roller; early larvae non-dumpy. ES3 ME1. NA > 10 (e115 sc38ts sc78sd e489 (pka rol-2) etc.). |
| | | See dpy-2. |
| | | See also e115, e487, e489, e961, e1280, e1359 |
| | | [C.elegansII] e8 : dumpy left roller; early larvae non-dumpy. Suppresses some alleles of glp-1, emb-5. ES3 ME1. OA>10: e115, sc38ts, sc78sd,e489 (pka rol-2), e961, q292 etc. Cloned: encodes collagen, 41% identical to adjacent gene dpy-10. [Brenner 1974; Levy et al. 1993; CH] |
| | Strain (15) |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00044941 |
| | | 00044942 |
| | | 00044943 |
| | | 00044944 |
| | | 00044945 |
| | | 00044946 |
| | | 00044947 |
| | | 00044948 |
| | | 00108188 |
| | Ortholog (29) |
| | Paralog (162) |
| | Structured_description | Concise_description | The dpy-2 gene encodes an unusual cuticular collagen that is required for maintaining the normal body length of the animal in later larval stages; dpy-2 interacts with other cuticular collagens such as dpy-10 and sqt-1, and suppresses mutations in glp-1, mup-1, and emb-5. | Paper_evidence | WBPaper00001792 |
| | | | | | WBPaper00003853 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to be a structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle; post-embryonic body morphogenesis; and regulation of growth. Predicted to be part of collagen trimer. Expressed in head neurons and pharynx. Used to study skin disease. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:37 | Homo sapiens | Paper_evidence | WBPaper00061220 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 02 May 2022 00:00:00 |
| Models_disease_in_annotation | WBDOannot00001173 |
| Molecular_info | Corresponding_CDS | T14B4.6 |
| | Corresponding_transcript | T14B4.6.1 |
| | Other_sequence (15) |
| | Associated_feature | WBsf644316 |
| | | WBsf657711 |
| | | WBsf221491 |
| | | WBsf221492 |
| Experimental_info | RNAi_result (23) |
| | Expr_pattern | Expr4481 |
| | | Expr4482 |
| | | Expr1024298 |
| | | Expr1030673 |
| | | Expr1156898 |
| | | Expr2011070 |
| | | Expr2029307 |
| | Drives_construct | WBCnstr00012049 |
| | | WBCnstr00012050 |
| | | WBCnstr00037107 |
| | Construct_product | WBCnstr00037107 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00033070:Elbe_downregulated |
| | | WBPaper00033070:Rhine_downregulated |
| | | WBPaper00035197:fer-1_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:hypodermis_embryo_enriched |
| | | WBPaper00037950:hypodermis_embryo_SelectivelyEnriched |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00040560:hpl-2_L3_upregulated |
| | | WBPaper00041954:ethanol_upregulated |
| | | WBPaper00042477:prp-8(RNAi)_downregulated_RNAseq |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq |
| | | WBPaper00043945:MeHg_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045257:bar-1(ga80)_downregulated |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set2 |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048611:MnCl2_upregulated |
| | | WBPaper00049098:heat-induced_hrde-1(tm1200) |
| | | WBPaper00049334:CE_intestine_enriched |
| | | WBPaper00049498:npr-1(ur89)_regulated_1 |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(+) |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo |
| | | WBPaper00050182:lmn-1(L535P)_upregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050801:DAF-12_dauer_regulome |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050801:DPY-21_dauer_regulome |
| | | WBPaper00050843:sesamin_downregulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051265:F1_hrde-1(tm1200)_downregulated |
| | | WBPaper00051265:F4_hrde-1(tm1200)_downregulated |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00051371:Orsay-virus-infection_upregulated_rde-1(ne219) |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051404:alg-2(ok304)_downregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053020:sid-3(ok973)_upregulated |
| | | WBPaper00053020:sta-1(ok587)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_downregulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053318:Aging_downregulated_mRNA_N2 |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053657:N2_M.humicola-infection_24hr |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated |
| | | WBPaper00054410:set-9(rw5)_downregulated |
| | | WBPaper00054410:set-26(tm2467)_downregulated |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055013:hmg-3(bar24)_downregulated |
| | | WBPaper00055013:spt-16(RNAi)_downregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055386:daf-2(e1370)_upregulated |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055897:heat-shock_upregulated |
| | | WBPaper00055941:atfs-1(et15)_upregulated |
| | | WBPaper00055944:C.butyricum_vs_OP50_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056169:rrf-3(pk1426)_downregulated_L4 |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_L1 |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated |
| | | WBPaper00056330:glycine_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056617:adr-1_upregulated_L4_transcript |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057149:prgn-1(tm985)_downregulated |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00057347:nhr-14(tm1473)_downreglated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058927:high-redox-state_upregulated |
| | | WBPaper00059117:B.subtilis_upregulated |
| | | WBPaper00059231:alh-6(lax105)_L4_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059735:glucose_upregulated_lpin-1(RNAi) |
| | | WBPaper00059735:glucose_upregulated_N2 |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_adult |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060084:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060273:vrk-1(RNAi)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060434:pH4.33_vs_pH6.33_downrgulated |
| | | WBPaper00060445:ikb-1(nr2027)_downregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_downregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_downregulated_L4 |
| | | WBPaper00060526:plp-1(ok2155)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060744:Radiation_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:HB115_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061007:X.citri_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061340:G2_and_W_blasts |
| | | WBPaper00061340:hyp4_hyp5_hyp6 |
| | | WBPaper00061340:hyp7_AB_lineage |
| | | WBPaper00061340:hyp7_C_lineage |
| | | WBPaper00061340:Hypodermis |
| | | WBPaper00061340:P_cell |
| | | WBPaper00061340:Seam_cell |
| | | WBPaper00061340:Tail_hypodermis |
| | | WBPaper00061340:Y |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061479:hrde-1(tm1200)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:mlt-9_22518-F33D4.6_14044 |
| | | WBPaper00061530:nhr-49(e2144)_downregulated |
| | | WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00061653:alh-4(hj221)_downregulated |
| | | WBPaper00062156:jmjd-1.2(zr1010)_upregulated |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062497:xpf-1(tm2842)_upregulated |
| | | WBPaper00062534:fat-P-80_downregulated |
| | | WBPaper00062534:fat-P-80_downregulated_ech-6(RNAi) |
| | | WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium |
| | | WBPaper00062715:blmp-1(s71)_upregulated |
| | | WBPaper00063926:chd-7(gk290)_upregulated |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064403:Heat-killed-E.Coli_upregulated |
| | | WBPaper00064494:postdauer_upregulated_AWA |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00064788:ketamine_upregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:25C_vs_15C_upregulated_AFD |
| | | WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal |
| | | WBPaper00065560:E.coli-HB101_downregulated_F3 |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065746:eat-2(ad1113)_downregulated |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065945:global-rpoa-2(-)_downregulated_transcript |
| | | WBPaper00065984:pals-17(syb3980)_downregulated |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Cisplatin_upregulated_diploid |
| | | WBPaper00066110:Doxorubicin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066232:ash-2(RNAi)_upregulated_WT |
| | | cgc4386_cluster_5_6 |
| | | cgc4489_group_8 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_downregulated |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026629:L2_male_enriched |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026952:class_E |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00032948:FedUp |
| | | WBPaper00032948:MoltOssilate |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00034739:RIL17lessRIL14 |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00036383:ash-2_L3_regulated |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00037695:WC_CC_6-day |
| | | WBPaper00038172:aak-2overexpression_down_regulated |
| | | WBPaper00040185:nhr-23(RNAi)_downregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5 |
| | | WBPaper00040823:alg-1(gk214)_upregulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:environmental_prime |
| | | WBPaper00041207:CE_dauer_down |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00042128:gei-8(ok1671)_downregulated |
| | | WBPaper00042258:DA1877_downregulated_YoungAdult |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00045865:biofilm_downregulated_A |
| | | WBPaper00045865:biofilm_downregulated_B |
| | | WBPaper00046083:oga-1(ok1207)_OP50_downregulated |
| | | WBPaper00046083:pmk-1(km25)_OP50_downregulated |
| | | WBPaper00046548:dafachronic-acid_upregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00049311:sAg-MNP_regulated |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | [cgc6390]:Cluster_B |
| | Interaction (192) |
| | WBProcess | WBbiopr:00000124 |
| Map_info | Map | II | Position | 0.042787 | Error | 0.009724 |
| | Well_ordered |
| | Positive | Inside_rearr | arDp2 |
| | | Positive_clone | T14B4 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 36 |
| | | | 47 |
| | | | 217 |
| | | | 6101 |
| | | | 7051 |
| | | Multi_point (17) |
| | | Pos_neg_data (22) |
| Reference (73) |
| Method | Gene |