WormBase Tree Display for Gene: WBGene00001081
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| WBGene00001081 | Evidence | Paper_evidence | WBPaper00005632 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F47A4 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | dpy-22 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F47A4.2 | ||||||||
| Molecular_name | F47A4.2 | ||||||||
| F47A4.2.1 | |||||||||
| CE16058 | |||||||||
| Other_name | psa-6 | ||||||||
| sop-1 | |||||||||
| mdt-12 | Author_evidence | Bourbon H-M | |||||||
| CELE_F47A4.2 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | dpy-22 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dpy | ||||||||
| Reference_allele | WBVar00143373 | ||||||||
| Allele (185) | |||||||||
| Legacy_information | e652 : variable scrawny dumpy slow-growing (XX); very abnormal small or inviable male (XO). ES2 (all stages XX) ES3 (all stages XO). ME0. NA1. | ||||||||
| See also e652 | |||||||||
| [C.elegansII] e652 : variable, scrawny, dumpy slow-growing (XX); very abnormal small or inviable male (XO); reduced X chromosome expression. ES2 (all stages XX) ES3 (all stages XO). ME0. NA1. [Meneely and Wood 1987; Plenefisch et al. 1989] | |||||||||
| [Zhang H, Emmons SW] bx92 is suppressor of pal-1(e2091) V ray defect; other alleles similar. | |||||||||
| Strain | WBStrain00002971 | ||||||||
| WBStrain00030931 | |||||||||
| WBStrain00030944 | |||||||||
| WBStrain00004192 | |||||||||
| WBStrain00007179 | |||||||||
| WBStrain00007180 | |||||||||
| WBStrain00007183 | |||||||||
| WBStrain00007184 | |||||||||
| WBStrain00008473 | |||||||||
| WBStrain00008474 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00004161 | ||||||||
| Structured_description | Concise_description | dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression. | Paper_evidence | WBPaper00005068 | |||||
| WBPaper00005632 | |||||||||
| WBPaper00012788 | |||||||||
| WBPaper00012830 | |||||||||
| WBPaper00012882 | |||||||||
| WBPaper00012897 | |||||||||
| WBPaper00013003 | |||||||||
| Curator_confirmed | WBPerson625 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable transcription coactivator activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and negative regulation of vulval development. Located in nucleus. Expressed in several structures, including hypodermal cell; intestine; pharynx; and vulva. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); major depressive disorder; and phobic disorder. Is an ortholog of human MED12L (mediator complex subunit 12L). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:14711 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11957) | ||||
| DOID:591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11957) | ||||||
| DOID:1967 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11957) | ||||||
| DOID:1470 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11957) | ||||||
| DOID:0080985 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11957) | ||||||
| Molecular_info | Corresponding_CDS | F47A4.2 | |||||||
| Corresponding_transcript | F47A4.2.1 | ||||||||
| Other_sequence | JI164168.1 | ||||||||
| ACC20072_1 | |||||||||
| JI164145.1 | |||||||||
| FC543403.1 | |||||||||
| Associated_feature | WBsf670899 | ||||||||
| WBsf670900 | |||||||||
| WBsf1006541 | |||||||||
| WBsf1023629 | |||||||||
| WBsf237797 | |||||||||
| Transcription_factor | WBTranscriptionFactor000276 | ||||||||
| Experimental_info | RNAi_result (77) | ||||||||
| Expr_pattern | Chronogram1297 | ||||||||
| Expr2021 | |||||||||
| Expr2271 | |||||||||
| Expr3489 | |||||||||
| Expr13299 | |||||||||
| Expr1022403 | |||||||||
| Expr1030688 | |||||||||
| Expr1151427 | |||||||||
| Expr2011065 | |||||||||
| Expr2029302 | |||||||||
| Drives_construct | WBCnstr00003476 | ||||||||
| WBCnstr00010744 | |||||||||
| WBCnstr00011421 | |||||||||
| WBCnstr00037092 | |||||||||
| Construct_product | WBCnstr00010744 | ||||||||
| WBCnstr00011421 | |||||||||
| WBCnstr00016104 | |||||||||
| WBCnstr00037092 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (138) | |||||||||
| Interaction (126) | |||||||||
| WBProcess | WBbiopr:00000071 | ||||||||
| WBbiopr:00000072 | |||||||||
| Map_info | Map | X | Position | 1.71011 | Error | 0.006646 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F47A4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 624 | |||||||
| 3153 | |||||||||
| 3156 | |||||||||
| Multi_point | 531 | ||||||||
| 532 | |||||||||
| 533 | |||||||||
| 1195 | |||||||||
| 1196 | |||||||||
| 3927 | |||||||||
| 3928 | |||||||||
| 3929 | |||||||||
| 3930 | |||||||||
| 4061 | |||||||||
| Pos_neg_data | 3154 | ||||||||
| 249 | |||||||||
| 872 | |||||||||
| Landmark_gene | |||||||||
| Reference (63) | |||||||||
| Remark | psa-6 is allelic with dpy-22 [Sawa H] | ||||||||
| sop-1 is allelic with dpy-22 [Sawa H] | |||||||||
| Method | Gene |
