| WBGene00001555 | SMap | S_parent | Sequence | T04D3 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | gcy-35 | Person_evidence | WBPerson655 |
| | | Sequence_name | T04D3.4 |
| | | Molecular_name | T04D3.4a |
| | | | T04D3.4a.1 |
| | | | CE34497 |
| | | | T04D3.4b |
| | | | CE46771 |
| | | | T04D3.4c |
| | | | CE46565 |
| | | | T04D3.4b.1 |
| | | | T04D3.4c.1 |
| | | Other_name | CeGC1 | Paper_evidence | WBPaper00003629 |
| | | | CELE_T04D3.4 | Accession_evidence | NDB | BX284601 |
| | | Public_name | gcy-35 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | gcy |
| | Allele (189) |
| | Strain | WBStrain00005284 |
| | | WBStrain00040838 |
| | | WBStrain00040844 |
| | | WBStrain00031618 |
| | | WBStrain00000304 |
| | | WBStrain00005280 |
| | RNASeq_FPKM (74) |
| | GO_annotation (35) |
| | Ortholog (46) |
| | Paralog (36) |
| | Structured_description | Concise_description | gcy-35 encodes a soluble guanylyl cyclase; GCY-35 activity is required for regulation of aggregation, aerotaxis, aerokinesis, gustatory plasticity, and innate immunity; GCY-35 activity is also required in the URX sensory neurons to sense increases in O2 levels and effect corresponding behavioral changes; gcy-35::gfp reporter fusions are expressed in a number of neurons, including the AQR, PQR, and URX sensory neurons, the SDQL/R and BDU interneurons, the AVM and PVM mechanosensory neurons, the cholinergic ALN and PLN neurons, the excretory cell, and in pharyngeal and body wall muscles; gcy-35 expression in the URX neuron is positively regulated by the AHR-1 transcription complex; the heme-binding domain of GCY-35 binds molecular oxygen as well as NO and CO. | Paper_evidence | WBPaper00003992 |
| | | | | | WBPaper00024211 |
| | | | | | WBPaper00024217 |
| | | | | | WBPaper00027029 |
| | | | | | WBPaper00027202 |
| | | | | | WBPaper00028350 |
| | | | | | WBPaper00028424 |
| | | | | | WBPaper00032196 |
| | | | | | WBPaper00033008 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 24 Aug 2011 00:00:00 |
| | | Automated_description | Enables carbon monoxide binding activity; nitric oxide binding activity; and oxygen sensor activity. Involved in several processes, including aerotaxis; cGMP-mediated signaling; and response to hyperoxia. Located in dendrite and neuronal cell body. Expressed in body wall musculature and pharyngeal muscle cell. Is an ortholog of human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T04D3.4a |
| | | T04D3.4b |
| | | T04D3.4c |
| | Corresponding_CDS_history | T04D3.4:wp104 |
| | Corresponding_transcript | T04D3.4a.1 |
| | | T04D3.4b.1 |
| | | T04D3.4c.1 |
| | Other_sequence | Dviv_isotig23790 |
| | | BXC01727_1 |
| | | HBC26375_1 |
| | | EX912238.1 |
| | | JK314899.1 |
| | | DW718336.1 |
| | Associated_feature (14) |
| Experimental_info | RNAi_result | WBRNAi00062075 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00035139 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00052391 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00000597 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00022435 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00000627 |
| | | WBCnstr00000629 |
| | | WBCnstr00001835 |
| | | WBCnstr00011061 |
| | | WBCnstr00011066 |
| | | WBCnstr00036865 |
| | Construct_product | WBCnstr00020209 |
| | | WBCnstr00036865 |
| | | WBCnstr00039997 |
| | | WBCnstr00041898 |
| | Antibody | WBAntibody00001649 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00037682:sma-2_downregulated |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040420:ALM_PLM_enriched |
| | | WBPaper00040420:FLP_enriched |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045861:wdr-5(ok1417)_upregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055354:Allantoin_upregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00057041:spc-1(cas971)_downregulated |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated |
| | | WBPaper00057162:meg-3_meg-4_upregulated_sRNA |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059117:B.subtilis_upregulated |
| | | WBPaper00059334:sacy-1(depletion)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060526:plp-1(ok2155)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061081:skpo-1(ok1640)_downregulated_OP50 |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:PLM |
| | | WBPaper00061340:URX |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:acy-2-F35C5.11 |
| | | WBPaper00061651:ALN_enriched |
| | | WBPaper00061651:AQR_enriched |
| | | WBPaper00061651:AVM_enriched |
| | | WBPaper00061651:BDU_enriched |
| | | WBPaper00061651:PLN_enriched |
| | | WBPaper00061651:PQR_enriched |
| | | WBPaper00061651:SDQ_enriched |
| | | WBPaper00061651:URX_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062118:neural-HSF-1_upregulated |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00064999:miR-229-64-65-66_upregulated |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:20_1 |
| | | WBPaper00065841:28_0 |
| | | WBPaper00065841:39_0 |
| | | WBPaper00065841:39_1 |
| | | WBPaper00065841:39_2 |
| | | WBPaper00065841:39_3 |
| | | WBPaper00065841:51_0 |
| | | WBPaper00065841:51_1 |
| | | WBPaper00065841:80_0 |
| | | WBPaper00065841:107_0 |
| | | WBPaper00065841:137_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066085:sin-3(tm1276)_upregulated |
| | | cgc4489_group_15 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (49) |
| | Anatomy_function | WBbtf0009 |
| | | WBbtf0343 |
| | | WBbtf0344 |
| | WBProcess | WBbiopr:00000039 |
| | | WBbiopr:00000054 |
| | | WBbiopr:00000063 |
| Map_info | Map | I | Position | 17.684 | Error | 0.174053 |
| | Positive | Positive_clone | T04D3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4680 |
| | Pseudo_map_position |
| Reference (59) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
