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WormBase Tree Display for Gene: WBGene00001580

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Name Class

WBGene00001580SMapS_parentSequenceCHROMOSOME_IV
IdentityVersion1
NameCGC_namegex-3Person_evidenceWBPerson419
Sequence_nameF28D1.10
Molecular_nameF28D1.10
F28D1.10.1
CE05750
Other_nameCELE_F28D1.10Accession_evidenceNDBBX284604
Public_namegex-3
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:25WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classgex
Allele (48)
StrainWBStrain00040419
WBStrain00024269
WBStrain00051117
WBStrain00055525
RNASeq_FPKM (74)
GO_annotation (26)
Ortholog (44)
Structured_descriptionConcise_descriptionThe gex-3 gene encodes a homolog of NAP1/NCKAP1, a mammalian protein ligand of the small GTPase Rac1, and of Drosophila HEM2/NAP1/KETTE; gex-3 is required for tissue morphogenesis and cell migrations; in gex-3 mutants, cells differentiate properly but fail to become organized.Paper_evidenceWBPaper00005149
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionInvolved in several processes, including egg-laying behavior; embryonic morphogenesis; and positive regulation of cellular component organization. Located in cell junction. Part of SCAR complex. Expressed in intestinal cell. Human ortholog(s) of this gene implicated in immunodeficiency 72. Is an ortholog of human NCKAP1 (NCK associated protein 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0112015Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4862)
Molecular_infoCorresponding_CDSF28D1.10
Corresponding_transcriptF28D1.10.1
Other_sequence (40)
Associated_featureWBsf646473
WBsf229287
WBsf229288
Experimental_infoRNAi_result (41)
Expr_patternExpr1828
Expr8395
Expr10794
Expr12485
Expr1017668
Expr1030946
Expr1149732
Expr2012024
Expr2030260
Drives_constructWBCnstr00013296
WBCnstr00036848
Construct_productWBCnstr00009364
WBCnstr00013296
WBCnstr00017546
WBCnstr00036848
AntibodyWBAntibody00000464
Microarray_results (22)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:germline_specific
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_downregulated
WBPaper00046303:P.aeruginosa_upregulated_protein
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049018:swsn-2.2(RNAi)_upregulated
WBPaper00049498:npr-1(ur89)_regulated_6
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050496:unc-39(hp701)_regulated
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:intestine_enriched
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00051265:F4_morc-1(tm6048)_upregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053289:DREAM-target
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:stavudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055648:germline_expressed
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056826:SGP_biased
WBPaper00059174:MEG-3_interacting
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060445:nfki-1(cer1)_upregulated_L4
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00061527:trcs-2_5724-R11A8.7_17645
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064505:tamoxifen_upregulated
WBPaper00064716:paraquat_upregulated
WBPaper00065096:25C_vs_20C_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:Doxorubicin_downregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_4
WBPaper00025032:cluster_162
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00034739:N2moreDR1350
WBPaper00035084:embryo_enriched_AIN-2_IP
WBPaper00035084:L2_enriched_AIN-2_IP
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00035084:L4_enriched_AIN-2_IP
WBPaper00035905:FBF-1_Associated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_F
WBPaper00037611:RNP-8-associated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040985:AIN-2_asynchronous_intestine
WBPaper00040985:AIN-2_L4_intestine
WBPaper00041002:HF_3d_2.0mM_Down
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00042548:miRISC_enriched
WBPaper00048563:L1_DD_enriched
WBPaper00048989:N2_rapamycin_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:cluster_13
[cgc5767]:expression_class_E
[cgc5767]:expression_class_ET
[cgc5767]:expression_class_ET_max(143_min)
[cgc5767]:expression_class_E_pi(101_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc5767]:expression_class_MET
[cgc6390]:Cluster_F
[cgc6390]:mixed_oogenesis-somatic
Interaction (100)
Map_infoPositivePositive_cloneF28D1Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4816
Interpolated_map_positionIV5.91283
Reference (37)
Remarkmost on F28D1.10; the 3' end on F08G5 (nucleotides 1 to 4576). predicted gene previously called CeHEM2; mammalian homolog is called HEM2 and NAP1, and the fly homolog is called KETTE. [Soto M]
MethodGene