WormBase Tree Display for Gene: WBGene00001597
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| WBGene00001597 | SMap | S_parent | Sequence | T07F8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gld-3 | Person_evidence | WBPerson555 | |||||
| Sequence_name | T07F8.3 | ||||||||
| Molecular_name | T07F8.3a | ||||||||
| T07F8.3a.1 | |||||||||
| CE42163 | |||||||||
| T07F8.3b | |||||||||
| CE28652 | |||||||||
| T07F8.3b.1 | |||||||||
| Other_name | CELE_T07F8.3 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | gld-3 | ||||||||
| DB_info | Database | AceView | gene | 2H427 | |||||
| WormQTL | gene | WBGene00001597 | |||||||
| WormFlux | gene | WBGene00001597 | |||||||
| NDB | locus_tag | CELE_T07F8.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001597|UniProtKB=Q95ZK7 | |||||||
| family | PTHR10627 | ||||||||
| NCBI | gene | 174174 | |||||||
| RefSeq | protein | NM_063078.4 | |||||||
| NM_063079.8 | |||||||||
| SwissProt | UniProtAcc | Q95ZK7 | |||||||
| TREEFAM | TREEFAM_ID | TF353300 | |||||||
| UniProt_GCRP | UniProtAcc | Q95ZK7 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gld | ||||||||
| Allele (53) | |||||||||
| Strain | WBStrain00022615 | ||||||||
| WBStrain00022623 | |||||||||
| WBStrain00022625 | |||||||||
| WBStrain00003944 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Ortholog (20) | |||||||||
| Paralog | WBGene00000246 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00007463 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | gld-3 encodes two KH domain-containing RNA-binding proteins, GLD-3L and GLD-3S, that are homologous to Drosophila Bicaudal-C; gld-3 activity is required for two aspects of germ line development: the sperm/oocyte and mitosis/meiosis decisions; in regulating the sperm/oocyte switch, GLD-3L acts by binding and negatively regulating FBF's regulatory interaction with the fem-3 3'UTR; in regulating the mitosis/meiosis decision, GLD-3 functions with GLD-2, the catalytic subunit of a poly (A) polymerase, and in parallel to GLD-1 and NOS-3, to positively regulate entry into meiosis as germ cells move away from the distal, mitotic region of the gonad; in contrast to the sperm/oocyte decision, gld-3 functions downstream of FBFs, which bind specifically to elements in the gld-3S 3'-UTR to regulate GLD-3 expression, in the mitosis/meiosis decision; gld-3 activity is also required for germline survival and early embryogenesis; GLD-3 is a cytoplasmic protein that is found in the early embryo and in the germline throughout development in both sexes; in the early embryo, GLD-3 is also seen in cytoplasmic particles, some of which are coincident with P granules. | Paper_evidence | WBPaper00005566 | |||||
| WBPaper00024407 | |||||||||
| WBPaper00028555 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Apr 2007 00:00:00 | ||||||||
| Automated_description | Enables polynucleotide adenylyltransferase activator activity and protein domain specific binding activity. Involved in several processes, including developmental process involved in reproduction; positive regulation of meiotic nuclear division; and vulval development. Located in P granule. Part of RNA-directed RNA polymerase complex. Expressed in germ line and in male. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T07F8.3a | |||||||
| T07F8.3b | |||||||||
| Corresponding_CDS_history | T07F8.3a:wp86 | ||||||||
| T07F8.3a:wp187 | |||||||||
| T07F8.3b:wp86 | |||||||||
| Corresponding_transcript | T07F8.3a.1 | ||||||||
| T07F8.3b.1 | |||||||||
| Other_sequence | CBC03502_1 | ||||||||
| CBC00759_1 | |||||||||
| CJC14646_1 | |||||||||
| CR09698 | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (26) | ||||||||
| Expr_pattern | Expr2269 | ||||||||
| Expr12329 | |||||||||
| Expr1025390 | |||||||||
| Expr1030958 | |||||||||
| Expr1156387 | |||||||||
| Expr2012088 | |||||||||
| Expr2030324 | |||||||||
| Construct_product | WBCnstr00021259 | ||||||||
| Antibody | WBAntibody00000574 | ||||||||
| WBAntibody00000575 | |||||||||
| WBAntibody00001931 | |||||||||
| WBAntibody00001934 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (200) | |||||||||
| Interaction (112) | |||||||||
| Map_info | Map | II | Position | 0.495502 | Error | 0.000121 | |||
| Positive | Positive_clone | T07F8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4349 | |||||||
| 4350 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (75) | |||||||||
| Picture | WBPicture0000013095 | ||||||||
| Remark | Sequence connection on the basis of PMID 12239571 [021008 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
