| WBGene00001653 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | K04D7 |
| Identity | Version | 1 |
| | Name | CGC_name | gon-4 | Person_evidence | WBPerson261 |
| | | Sequence_name | K04D7.5 |
| | | Molecular_name | K04D7.5a |
| | | | K04D7.5a.1 |
| | | | CE35579 |
| | | | K04D7.5b |
| | | | CE40976 |
| | | | K04D7.5b.1 |
| | | Other_name | CELE_K04D7.5 | Accession_evidence | NDB | BX284604 |
| | | Public_name | gon-4 |
| | DB_info | Database | WormQTL | gene | WBGene00001653 |
| | | | WormFlux | gene | WBGene00001653 |
| | | | NDB | locus_tag | CELE_K04D7.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001653|UniProtKB=Q21216 |
| | | | | family | PTHR16088 |
| | | | NCBI | gene | 177899 |
| | | | RefSeq | protein | NM_069463.7 |
| | | | | | NM_001129314.4 |
| | | | TREEFAM | TREEFAM_ID | TF343327 |
| | | | TrEMBL | UniProtAcc | A5JYS9 |
| | | | | | Q21216 |
| | | | UniProt_GCRP | UniProtAcc | Q21216 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | gon |
| | Allele (60) |
| | Legacy_information | [Santa Anna S] abnormal gonad development, vulva development mostly abnormal, some spermatogenesis, little oogenesis |
| | | [C.elegansII] e2575 : abnormal gonad development,sterile; vulva development mostly abnormal, some spermatogenesis, little oogenesis. Often failure of division of Z1, Z4.OA2: q519, q521. [CB; JK] |
| | Strain | WBStrain00022572 |
| | RNASeq_FPKM (74) |
| | GO_annotation (11) |
| | Ortholog (31) |
| | Structured_description | Concise_description | gon-4 encodes a large (1336-residue), unfamiliar, acidic (20% acidic residues and pI of 4.4), nuclear protein directly required for gonadogenesis in both sexes and, indirectly, for proper germ line and vulval development; gon-4 is expressed (and functionally required) in somatic gonadal cells during early gonadal development; while Z1 and Z4 (the somatic gonad precursor cells) appear to be specified correctly in gon-4 mutant L1 larvae, and other postembryonic events in somatic gonadal development appear to still occur at normal times, the postembryonic cell divisions of Z1 and Z4 are greatly delayed or missing in gon-4 larvae; GON-4 is subtly similar to human HCCA2 (OMIM:607860, expression associated with hepatocellular carcinoma). | Paper_evidence | WBPaper00002921 |
| | | | | | WBPaper00004450 |
| | | | | | WBPaper00006002 |
| | | | | | WBPaper00012909 |
| | | | | | WBPaper00013005 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable transcription coregulator activity. Involved in gonad development and positive regulation of cell division. Located in germ cell nucleus. Expressed in germ line and gonad. Is an ortholog of human GON4L (gon-4 like) and YY1AP1 (YY1 associated protein 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | K04D7.5a |
| | | K04D7.5b |
| | Corresponding_CDS_history | K04D7.5:wp109 |
| | Corresponding_transcript | K04D7.5a.1 |
| | | K04D7.5b.1 |
| | Other_sequence | EX011699.1 |
| | | HGC11078_1 |
| | | CRC06302_1 |
| | | GO252559.1 |
| | | CR07997 |
| | | JI169027.1 |
| | | HG04263 |
| | Associated_feature | WBsf660570 |
| | | WBsf997574 |
| | | WBsf1018059 |
| | | WBsf228959 |
| | | WBsf228960 |
| Experimental_info | RNAi_result | WBRNAi00033945 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00049898 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00083932 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00083931 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00001239 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00064058 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00008225 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00016591 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00084461 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr957 |
| | | Expr1021576 |
| | | Expr1030992 |
| | | Expr1153604 |
| | | Expr2012172 |
| | | Expr2030408 |
| | Drives_construct | WBCnstr00013823 |
| | Construct_product | WBCnstr00013823 |
| | Antibody | WBAntibody00001593 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:isp-1-1(qm150)_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(+) |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:body-muscle_enriched |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00054493:hpl-2(tm1489)_downregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055897:heat-shock_downregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:gut-microbiota_downregulated |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00057006:DietaryRestriction_downregulated |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00058886:anp-1(ok608)_downregulated |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:M1_parent |
| | | WBPaper00061340:M4_parent |
| | | WBPaper00061340:Neuroblast_ALA_RMED |
| | | WBPaper00061340:Neuroblast_IL1_IL2 |
| | | WBPaper00061340:Parents_of_PHsh_hyp8_hyp9 |
| | | WBPaper00061340:RIM_parent |
| | | WBPaper00061340:RME_LR_parent |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061527:pch-2-B0393.3 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062715:blmp-1(s71)_downregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs |
| | | WBPaper00064502:spe-44(fx110)_upregulated |
| | | WBPaper00064505:tamoxifen_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_5_2 |
| | | cgc4489_group_2 |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031060:2-deoxy-D-glucose_downregulated |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00040210:Chlorpyrifos_16C_regulated |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00041002:HF_3d_0.2mM_Down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00042258:DA1877_downregulated_GravidAdult |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048563:L1_DD_enriched |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (18) |
| Map_info | Map | IV | Position | 4.5597 | Error | 0.000479 |
| | Well_ordered |
| | Positive | Positive_clone | K04D7 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 2785 |
| | | | 4084 |
| | | | 4385 |
| | | Pos_neg_data | 7375 |
| Reference (13) |
| Remark | Sequence connection from [Friedman L] |
| Method | Gene |
