WormBase Tree Display for Gene: WBGene00001653

WBGene00001653 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: K04D7
  Identity: Version: 1
    Name: CGC_name: gon-4 Person_evidence: WBPerson261
      Sequence_name: K04D7.5
      Molecular_name: K04D7.5a
        K04D7.5a.1
        CE35579
        K04D7.5b
        CE40976
        K04D7.5b.1
      Other_name: CELE_K04D7.5 Accession_evidence: NDB BX284604
      Public_name: gon-4
    DB_info: Database: WormQTL gene WBGene00001653
        WormFlux gene WBGene00001653
        NDB locus_tag CELE_K04D7.5
        Panther gene CAEEL|WormBase=WBGene00001653|UniProtKB=Q21216
          family PTHR16088
        NCBI gene 177899
        RefSeq protein NM_069463.7
            NM_001129314.4
        TREEFAM TREEFAM_ID TF343327
        TrEMBL UniProtAcc A5JYS9
            Q21216
        UniProt_GCRP UniProtAcc Q21216
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gon
    Allele (60)
    Legacy_information: [Santa Anna S] abnormal gonad development, vulva development mostly abnormal, some spermatogenesis, little oogenesis
      [C.elegansII] e2575 : abnormal gonad development,sterile; vulva development mostly abnormal, some spermatogenesis, little oogenesis. Often failure of division of Z1, Z4.OA2: q519, q521. [CB; JK]
    Strain: WBStrain00022572
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog: WBGene00065663 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00026267 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00159697 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00192357 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00228286 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g8610 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g1941 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g7089 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g2507 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g22082 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g13657 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g2313 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g3401 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP40.g13099 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00925.g14962 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-gon-4 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold585.g4777 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00074.g3452 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_04754 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_014360 Caenorhabditis remanei From_analysis: WormBase-Compara
      Sp34_40259200 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g11534 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00214132 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00237232 Onchocerca volvulus From_analysis: WormBase-Compara
      FB:FBgn0085444 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-070117-2447 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-060503-728 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      HGNC:25973 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      HGNC:30935 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:1917579 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      RGD:1564691 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
    Structured_description: Concise_description: gon-4 encodes a large (1336-residue), unfamiliar, acidic (20% acidic residues and pI of 4.4), nuclear protein directly required for gonadogenesis in both sexes and, indirectly, for proper germ line and vulval development; gon-4 is expressed (and functionally required) in somatic gonadal cells during early gonadal development; while Z1 and Z4 (the somatic gonad precursor cells) appear to be specified correctly in gon-4 mutant L1 larvae, and other postembryonic events in somatic gonadal development appear to still occur at normal times, the postembryonic cell divisions of Z1 and Z4 are greatly delayed or missing in gon-4 larvae; GON-4 is subtly similar to human HCCA2 (OMIM:607860, expression associated with hepatocellular carcinoma). Paper_evidence: WBPaper00002921
            WBPaper00004450
            WBPaper00006002
            WBPaper00012909
            WBPaper00013005
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable transcription coregulator activity. Involved in gonad development and positive regulation of cell division. Located in germ cell nucleus. Expressed in germ line and gonad. Is an ortholog of human GON4L (gon-4 like) and YY1AP1 (YY1 associated protein 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K04D7.5a
      K04D7.5b
    Corresponding_CDS_history: K04D7.5:wp109
    Corresponding_transcript: K04D7.5a.1
      K04D7.5b.1
    Other_sequence: EX011699.1
      HGC11078_1
      CRC06302_1
      GO252559.1
      CR07997
      JI169027.1
      HG04263
    Associated_feature: WBsf660570
      WBsf997574
      WBsf1018059
      WBsf228959
      WBsf228960
  Experimental_info: RNAi_result: WBRNAi00033945 Inferred_automatically: RNAi_primary
      WBRNAi00049898 Inferred_automatically: RNAi_primary
      WBRNAi00083932 Inferred_automatically: RNAi_primary
      WBRNAi00083931 Inferred_automatically: RNAi_primary
      WBRNAi00001239 Inferred_automatically: RNAi_primary
      WBRNAi00064058 Inferred_automatically: RNAi_primary
      WBRNAi00008225 Inferred_automatically: RNAi_primary
      WBRNAi00016591 Inferred_automatically: RNAi_primary
      WBRNAi00084461 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr957
      Expr1021576
      Expr1030992
      Expr1153604
      Expr2012172
      Expr2030408
    Drives_construct: WBCnstr00013823
    Construct_product: WBCnstr00013823
    Antibody: WBAntibody00001593
    Microarray_results (19)
    Expression_cluster (130)
    Interaction (18)
  Map_info: Map: IV Position: 4.5597 Error: 0.000479
    Well_ordered
    Positive: Positive_clone: K04D7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 2785
        4084
        4385
      Pos_neg_data: 7375
  Reference (13)
  Remark: Sequence connection from [Friedman L]
  Method: Gene