WormBase Tree Display for Gene: WBGene00001827
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| WBGene00001827 | SMap | S_parent | Sequence | C46A5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hcf-1 | |||||||
| Sequence_name | C46A5.9 | ||||||||
| Molecular_name | C46A5.9 | ||||||||
| C46A5.9.1 | |||||||||
| CE26914 | |||||||||
| Other_name | CELE_C46A5.9 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | hcf-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hcf | ||||||||
| Allele (41) | |||||||||
| Strain | WBStrain00031490 | ||||||||
| WBStrain00040638 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Contained_in_operon | CEOP4614 | ||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00009978 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00013461 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021751 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | hcf-1 encodes the C. elegans ortholog of human host cell factor (HCF-1), a transcriptional regulator that associates with histone modification enzymes and plays a role in cell cycle progression; in C. elegans, hcf-1 plays a role in regulation of cell division and mitotic histone modification; in addition, HCF-1 functions in determination of adult lifespan as a negative regulator of DAF-16, with which it physically interacts; HCF-1 is a ubiquitously expressed protein that localizes to the nucleus. | Paper_evidence | WBPaper00031249 | |||||
| WBPaper00032232 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Dec 2009 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and regulation of DNA-templated transcription. Acts upstream of or within defense response to other organism and response to endoplasmic reticulum stress. Located in nucleus. Part of transcription regulator complex. Expressed widely. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Is an ortholog of human HCFC1 (host cell factor C1) and HCFC2 (host cell factor C2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111814 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4839) | ||||
| Molecular_info | Corresponding_CDS | C46A5.9 | |||||||
| Corresponding_transcript | C46A5.9.1 | ||||||||
| Other_sequence (31) | |||||||||
| Associated_feature | WBsf651947 | ||||||||
| WBsf651948 | |||||||||
| WBsf230320 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00088935 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00042584 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081844 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108478 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081815 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062165 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081891 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012019 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081780 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108483 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00005314 | ||||||||
| WBCnstr00009024 | |||||||||
| WBCnstr00009025 | |||||||||
| WBCnstr00036664 | |||||||||
| Construct_product | WBCnstr00005314 | ||||||||
| WBCnstr00009025 | |||||||||
| WBCnstr00010947 | |||||||||
| WBCnstr00036664 | |||||||||
| Regulate_expr_cluster (17) | |||||||||
| Antibody | WBAntibody00000977 | ||||||||
| WBAntibody00001472 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (152) | |||||||||
| Interaction (118) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| Map_info | Map | IV | Position | 3.47224 | Error | 0.000901 | |||
| Positive | Positive_clone | C46A5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4397 | |||||||
| 4935 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (32) | |||||||||
| Remark | Sequence connection from [Liu Y, Hengartner MO, Herr W] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
