WormBase Tree Display for Gene: WBGene00001864

WBGene00001864 SMap: S_parent: Sequence: D1086
  Identity: Version: 2
    Name: CGC_name: him-5 Person_evidence: WBPerson261
      Sequence_name: D1086.4
      Molecular_name: D1086.4a
        D1086.4a.1
        CE09062
        D1086.4b
        CE45310
        D1086.4b.1
      Other_name: CELE_D1086.4 Accession_evidence: NDB BX284605
      Public_name: him-5
    DB_info: Database: WormQTL gene WBGene00001864
        WormFlux gene WBGene00001864
        NDB locus_tag CELE_D1086.4
        NCBI gene 183932
        RefSeq protein NM_001269627.3
            NM_001269626.2
        TrEMBL UniProtAcc O17724
            E1B6V2
        UniProt_GCRP UniProtAcc O17724
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 22 Aug 2008 17:09:12 WBPerson2970 Event: Acquires_merge: WBGene00008391
              Name_change: Sequence_name: D1086.4
      Acquires_merge: WBGene00008391
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: him
    Reference_allele: WBVar00144023
    Allele: WBVar00144023 Inferred_automatically (22)
      WBVar02149329 Inferred_automatically: From strain object: QP1398
      WBVar00089276
      WBVar00144041
      WBVar02157601
      WBVar01744327
      WBVar00598962
      WBVar00093091
      WBVar00476202
      WBVar00476203
      WBVar01065256
      WBVar01065257
      WBVar01065258
      WBVar01065259
      WBVar01065260
      WBVar01065261
      WBVar01065262
      WBVar01065263
      WBVar01065264
      WBVar01065265
      WBVar01065266
      WBVar01065267
      WBVar01065268
      WBVar01065269
      WBVar01065270
      WBVar01065271
      WBVar01499621
      WBVar02024586
      WBVar02024587
      WBVar02137516
      WBVar02137517
      WBVar00144039
      WBVar01500212
      WBVar01500213
      WBVar01499299
      WBVar00014980
      WBVar00014985
      WBVar00014990
      WBVar01462769
      WBVar01462770
      WBVar01499316
      WBVar01842726
      WBVar01842727
    Legacy_information: e1467ts : at 20x self-progeny 16% XO male 11% ova are nullo-X as a result of reductional meiotic nondisjunction; X chromosome recombination specifically reduced 50%. ES3 (progeny). ME3. NA2 (e1490 (stronger allele : 33% Him at 20x)).
      See also e1467, e1490
      [C.elegansII] e1467ts : at 20C self-progeny 16% XO male, 3% 3X herm, 11% ova are nullo-X as a result of reductional meiotic nondisjunction; X chromosome recombination specifically reduced 50% or more, except at left end (increased); additional sterility not due to autosomal nondisjunction ( brood reduced 64% at 25C); some embryonic lethality. ES3 (progeny). ME3. OA4: e1490 (stronger allele : 33% Him at 20C)). Cloned: cosmid rescue K02A12. [Hodgkin et al. 1979; Broverman and Meneely 1994; FH]
    Strain (490)
    RNASeq_FPKM (74)
    GO_annotation: 00008104
      00030516
      00030517
      00030518
    Ortholog: chrV_pilon.g16429 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: him-5 was identified in screens for genes that when mutated resulted in an increased frequency of X chromosome nondisjunction and thus, an increased frequency of genotypically XO males in self-fertile populations; him-5 functions in X chromosome dynamics by regulating the number and distribution of X chromosome pairing events. Paper_evidence: WBPaper00000179
            WBPaper00001852
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Oct 2010 00:00:00
      Automated_description: Involved in meiotic DNA double-strand break formation involved in reciprocal meiotic recombination and meiotic chromosome segregation. Located in condensed chromosome. Expressed in gonad. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: D1086.4a
      D1086.4b
    Corresponding_transcript: D1086.4a.1
      D1086.4b.1
    Associated_feature: WBsf647510
      WBsf232867
      WBsf232868
      WBsf232869
  Experimental_info: RNAi_result: WBRNAi00030368 Inferred_automatically: RNAi_primary
      WBRNAi00111474 Inferred_automatically: RNAi_primary
      WBRNAi00012552 Inferred_automatically: RNAi_primary
      WBRNAi00061770 Inferred_automatically: RNAi_primary
      WBRNAi00043422 Inferred_automatically: RNAi_primary
      WBRNAi00111473 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9917
      Expr1023729
      Expr1031097
      Expr1147415
      Expr2012430
      Expr2030666
    Drives_construct: WBCnstr00036641
      WBCnstr00038151
    Construct_product: WBCnstr00036641
      WBCnstr00038150
      WBCnstr00038151
    Microarray_results (18)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045861:wdr-5(ok1417)_downregulated
      WBPaper00048762:FOG-3_associated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00050015:ifg-1(RNAi)_downregulated
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_upregulated_WT_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Metformin_downregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057083:daf-2(e1370)rsks-1(ok1255)_post-transcriptional_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:mex-1(or286)_downregulated
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00059378:lmn-1(Y59C)_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061203:let-418(n3536)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:Germline
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:T22D1.5-inx-14
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064716:paraquat_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065199:Transgeneration-starvation_regulated_fed
      WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025032:cluster_41
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp2
      WBPaper00033101:spr-5_regulated
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037611:GLD-2-associated
      WBPaper00037611:RNP-8-associated
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_E
      [cgc6390]:oogenesis-enriched
    Interaction (68)
  Map_info: Map: V Position: 6.09216 Error: 0.018285
    Well_ordered
    Positive: Positive_clone: D1086 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 308
        6177
      Multi_point (33)
      Pos_neg_data: 1761
        4301
        6866
        7401
    Landmark_gene
  Reference (239)
  Remark: This locus was previously connected to Y54G2A.1 which was a mistake [030212 krb]
  Method: Gene