WormBase Tree Display for Gene: WBGene00001958

WBGene00001958 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C18A3
  Identity: Version: 1
    Name: CGC_name: hlh-14 Person_evidence: WBPerson346
      Sequence_name: C18A3.8
      Molecular_name: C18A3.8
        C18A3.8.1
        CE50415
      Other_name: CELE_C18A3.8 Accession_evidence: NDB BX284602
      Public_name: hlh-14
    DB_info: Database: AceView gene 2G28
        WormQTL gene WBGene00001958
        WormFlux gene WBGene00001958
        NDB locus_tag CELE_C18A3.8
        Panther gene CAEEL|WormBase=WBGene00001958|UniProtKB=Q09961
          family PTHR13935
        NCBI gene 182758
        RefSeq protein NM_062730.6
        SwissProt UniProtAcc Q09961
        TREEFAM TREEFAM_ID TF322889
        UniProt_GCRP UniProtAcc Q09961
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hlh
    Allele (24)
    Strain: WBStrain00028745
      WBStrain00035881
      WBStrain00051978
      WBStrain00055565
    RNASeq_FPKM (74)
    GO_annotation (26)
    Ortholog (22)
    Paralog: WBGene00001950 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001951 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001952 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: hlh-14 encodes a basic helix-loop-helix (bHLH) transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendants, including their cell division patterns, migrations, and neurotransmitter expression; in specifying neuronal cell fates, genetic evidence suggests that hlh-14 acts together with hlh-2, which encodes the C. elegans E/Daughterless ortholog; HLH-14 is expresed exclusively in the embryo and detected in the left and right PVQ/HSN/PHB neuroblasts and their descendants, as well as in other cells identified, tentatively, as anterior neuroblasts and posterior neuroblasts such as Caapa. Paper_evidence: WBPaper00006120
            WBPaper00006354
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Aug 2004 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; generation of neurons; and positive regulation of growth rate. Located in nucleus. Expressed in several structures, including ABplapppaap; ABplapppapa; ABprapppaap; ABprapppapa; and neurons. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C18A3.8
    Corresponding_CDS_history: C18A3.8:wp123
      C18A3.8:wp246
    Corresponding_transcript: C18A3.8.1
    Associated_feature: WBsf665555
      WBsf665556
      WBsf978629
      WBsf987944
      WBsf987945
      WBsf987946
      WBsf987947
      WBsf1012257
      WBsf223092
    Transcription_factor: WBTranscriptionFactor000078
      WBTranscriptionFactor000069
  Experimental_info: RNAi_result: WBRNAi00063335 Inferred_automatically: RNAi_primary
      WBRNAi00063336 Inferred_automatically: RNAi_primary
      WBRNAi00010963 Inferred_automatically: RNAi_primary
      WBRNAi00063334 Inferred_automatically: RNAi_primary
      WBRNAi00097167 Inferred_automatically: RNAi_primary
      WBRNAi00063333 Inferred_automatically: RNAi_primary
      WBRNAi00063332 Inferred_automatically: RNAi_primary
      WBRNAi00070165 Inferred_automatically: RNAi_primary
      WBRNAi00097170 Inferred_automatically: RNAi_primary
      WBRNAi00040888 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2897
      Expr9584
      Expr1011162
      Expr1031138
      Expr1144934
      Expr1200366
      Expr2012494
      Expr2030733
    Drives_construct: WBCnstr00000565
      WBCnstr00008859
      WBCnstr00008860
      WBCnstr00008861
      WBCnstr00008862
      WBCnstr00036560
    Construct_product: WBCnstr00036560
    Microarray_results (18)
    Expression_cluster (157)
    Interaction (67)
  Map_info: Map: II Position: -0.957536 Error: 0.000329
    Positive: Positive_clone: C18A3 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (23)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene