| WBGene00001966 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | C17C3 |
| Identity | Version | 2 |
| | Name | CGC_name | hlh-27 | Person_evidence | WBPerson346 |
| | | Sequence_name | C17C3.10 |
| | | Molecular_name | C17C3.10 |
| | | | C17C3.10.1 |
| | | | CE46787 |
| | | Other_name | CELE_C17C3.10 | Accession_evidence | NDB | BX284602 |
| | | Public_name | hlh-27 |
| | DB_info | Database | AceView | gene | 2F828 |
| | | | WormQTL | gene | WBGene00001966 |
| | | | WormFlux | gene | WBGene00001966 |
| | | | NDB | locus_tag | CELE_C17C3.10 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001966|UniProtKB=Q18056 |
| | | | | family | PTHR10985 |
| | | | NCBI | gene | 182719 |
| | | | RefSeq | protein | NM_062664.4 |
| | | | TREEFAM | TREEFAM_ID | TF322171 |
| | | | TrEMBL | UniProtAcc | Q18056 |
| | | | UniProt_GCRP | UniProtAcc | Q18056 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 03 Oct 2011 10:56:13 | WBPerson1867 | Event | Split_into | WBGene00219272 |
| | | Split_into | WBGene00219272 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | hlh |
| | Allele (17) |
| | Strain | WBStrain00051158 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00060095 |
| | | 00060096 |
| | | 00060097 |
| | | 00060098 |
| | | 00060099 |
| | | 00060100 |
| | | 00109819 |
| | Ortholog (22) |
| | Paralog | WBGene00001964 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001965 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00003008 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00001968 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00001967 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | hlh-27 encodes a REF-1-like protein with two bHLH domains, that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-25, HLH-26, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-27 may require UNC-37; HLH-27's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; hlh-27 is transcribed in the early MS lineage, probably due to MED-1/2 binding of clustered sites in the hlh-27 promoter region; HLH-27 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-27 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage, in a SKN-1-dependent manner; HLH-27 is required for embryonic viability in mass RNAi assays. | Paper_evidence | WBPaper00006395 |
| | | | | | WBPaper00025235 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 18 Apr 2008 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including ABpla; ABplp; ABprp; MSaa; and MSpa. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C17C3.10 |
| | Corresponding_CDS_history | C17C3.10:wp228 |
| | Corresponding_transcript | C17C3.10.1 |
| | Associated_feature | WBsf978830 |
| | | WBsf981202 |
| | | WBsf223060 |
| | Transcription_factor | WBTranscriptionFactor000074 |
| Experimental_info | RNAi_result | WBRNAi00010905 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00010899 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00084010 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00040773 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00024579 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00040785 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027179 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr3496 |
| | | Expr8068 |
| | | Expr1028370 |
| | | Expr1144810 |
| | | Expr2012502 |
| | | Expr2030741 |
| | Drives_construct | WBCnstr00005213 |
| | | WBCnstr00011428 |
| | | WBCnstr00015158 |
| | | WBCnstr00036554 |
| | Construct_product | WBCnstr00005213 |
| | | WBCnstr00016893 |
| | | WBCnstr00036554 |
| | Microarray_results | SMD_C17C3.10 |
| | | SMD_C17C3.11 |
| | | A_12_P151226 |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050712:RC301_vs_DA650_4h-PA_upregulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00056169:rrf-3(pk1426)_downregulated_embryo |
| | | WBPaper00056284:ints-5(RNAi)_upregulated |
| | | WBPaper00058598:mex-1(or286)_downregulated |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058955:heatshock_upregulated_CE |
| | | WBPaper00059117:B.subtilis_downregulated |
| | | WBPaper00059426:Ag-nanoparticles_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00061040:eat-2(ad1116)_upregulated |
| | | WBPaper00061081:E.faecalis_downregulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061424:Diet_MYb120_downregulated |
| | | WBPaper00061424:Diet_MYb131_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064661:lpd-3(ok2138)_downregulated |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Cisplatin_downregulated_diploid |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066232:ash-2(RNAi)_upregulated_WT |
| | | cgc4489_group_9 |
| | | cgc4489_group_10 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | [cgc6390]:spermatogenesis-enriched |
| | Interaction (182) |
| Map_info | Map | II | Position | -1.18532 | Error | 0.00229 |
| | Positive | Positive_clone | C17C3 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00025235 |
| | WBPaper00027287 |
| | WBPaper00027309 |
| | WBPaper00029033 |
| | WBPaper00034761 |
| | WBPaper00062117 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
