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WormBase Tree Display for Gene: WBGene00001978

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Name Class

WBGene00001978SMapS_parentSequenceR13H4
IdentityVersion1
NameCGC_namehmp-1Person_evidenceWBPerson498
Sequence_nameR13H4.4
Molecular_name (19)
Other_nameCELE_R13H4.4Accession_evidenceNDBBX284605
Public_namehmp-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhmp
Allele (102)
Legacy_information[C.elegansII] Mutations zygotic lethal, arrest at 1.25-1.5 fold stage with lumps in dorsal hypoderm. Cloned: encodes probable alpha-catenin homolog. [JJ]
StrainWBStrain00001826
WBStrain00022476
WBStrain00024213
WBStrain00030631
RNASeq_FPKM (74)
GO_annotation (27)
Ortholog (47)
ParalogWBGene00000832Caenorhabditis elegansFrom_analysisTreeFam
WormBase-Compara
WBGene00000942Caenorhabditis elegansFrom_analysisTreeFam
WormBase-Compara
Structured_descriptionConcise_descriptionhmp-1 encodes an alpha-catenin; during development, hmp-1 activity is required for proper enclosure and elongation of the embryo; HMP-1 localizes to hypodermal adherens junctions.Paper_evidenceWBPaper00003046
Curator_confirmedWBPerson1843
Date_last_updated11 Jun 2008 00:00:00
Automated_descriptionEnables actin filament binding activity and beta-catenin binding activity. Involved in several processes, including cortical actin cytoskeleton organization; embryonic morphogenesis; and regulation of actin cytoskeleton organization. Located in adherens junction and apical junction complex. Part of catenin complex. Expressed in several structures, including distal tip cell; germ cell; intestinal cell; neuroblasts; and pharyngeal cell. Human ortholog(s) of this gene implicated in several diseases, including arrhythmogenic right ventricular dysplasia 13; cervix uteri carcinoma in situ; and urinary system cancer (multiple). Is an ortholog of human CTNNA2 (catenin alpha 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:8991Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2509)
DOID:11054Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2509)
DOID:0090131Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2510)
DOID:2671Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2509)
DOID:0060864Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2509)
DOID:0110084Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2511)
DOID:4450Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2509)
DOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2509)
DOID:3457Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2509)
Molecular_infoCorresponding_CDSR13H4.4a
R13H4.4b
R13H4.4c
R13H4.4d
R13H4.4e
R13H4.4f
Corresponding_transcriptR13H4.4a.1
R13H4.4b.1
R13H4.4c.1
R13H4.4d.1
R13H4.4e.1
R13H4.4f.1
R13H4.4f.2
Other_sequence (49)
Associated_feature (11)
Experimental_infoRNAi_result (18)
Expr_patternChronogram912
Expr6534
Expr9341
Expr13047
Expr14677
Expr1011130
Expr1031148
Expr1155584
Expr2012529
Expr2030768
Drives_constructWBCnstr00002622
WBCnstr00004619
WBCnstr00006235
WBCnstr00007873
WBCnstr00008029
WBCnstr00009117
WBCnstr00020495
WBCnstr00036545
Construct_productWBCnstr00020495
WBCnstr00036545
AntibodyWBAntibody00000167
WBAntibody00001450
WBAntibody00002691
Microarray_results (30)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00032031:DConiospora_downregulated_OligoArray_24h
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00040221:DAF-12_target_ALF4
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_upregulated_HeatShock
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Oogenic
WBPaper00046509:htz-1(ok3099)_upregulated
WBPaper00048988:neuron_expressed
WBPaper00049159:Microwave_upregulated_adult
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_downregulated_N2
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:cytoplasm_specific
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053599:female_vs_male_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055648:germline_expressed
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056826:hmc_biased
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00059174:MEG-3_interacting
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059471:EGL-43_interacting
WBPaper00059987:Wounding_upregulated
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061274:hypergravity_15xg_upregulated
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:cids-2_2203-attf-2_2451
WBPaper00061527:clr-1_21440-mtm-3_16030
WBPaper00061527:ldb-1_2877-scd-1_3086
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062554:MAGU-2_interacting
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064201:SNA-3_interacting
WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
WBPaper00064315:mes-3(bn199)_upregulated_EGCs
WBPaper00064716:paraquat_upregulated
WBPaper00065096:25C_vs_20C_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065258:anchor-cell_enriched
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4386_cluster_6_3
cgc4489_group_2
WBPaper00025032:cluster_12
WBPaper00025032:cluster_39
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035905:FBF-1_Associated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_F
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00038231:Cry5B_2-fold_upregulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040823:alg-1(gk214)_downregulated
WBPaper00040963:TA100_down
WBPaper00040963:TA300_down
WBPaper00041002:HF_3d_2.0mM_Down
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00042258:DA1877_downregulated_GravidAdult
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:cluster_2
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(83_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:Cluster_F
[cgc6390]:oogenesis-enriched
Interaction (117)
WBProcessWBbiopr:00000017
Map_infoMapVPosition3.46447Error0.012439
PositivePositive_cloneR13H4Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4408
5036
Pseudo_map_position
Reference (108)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene